High Quality 99% Veterinary Raw Powder Erythromycin thiocyanate CAS 7704-67-8 with ready stock and fast delivery

Erythromycin thiocyanate More Info

Erythromycin thiocyanate is the thiocyanate salt form of erythromycin, a broad-spectrum macrolide antibiotic. It shares the same antibacterial properties and mechanism of action as erythromycin but is formulated as the thiocyanate salt for stability or specific applications.

Mechanism of Action

Erythromycin thiocyanate inhibits bacterial protein synthesis by binding to the 23S rRNA of the 50S ribosomal subunit in susceptible bacteria. This binding blocks peptide bond formation and translocation during protein synthesis, preventing bacterial growth and replication. It acts primarily as a bacteriostatic agent but can be bactericidal at higher concentrations. Resistance often arises from mutations in the 50S ribosomal subunit that prevent erythromycin binding.

Applications

Effective against a broad range of Gram-positive bacteria, including Staphylococcus aureus (including some penicillin-resistant strains), Streptococcus species, and Streptococcus pneumoniae.
Also active against certain Gram-negative bacteria and Mycoplasma.
Used primarily in research settings rather than direct clinical use; it serves as an antibacterial agent in microbiological and biochemical applications.
Has a similar antibacterial spectrum to benzylpenicillin.
Not intended for human or animal medicinal use in its thiocyanate salt form.

Safety and Side Effects

May cause allergic skin reactions, respiratory sensitization, and serious eye irritation upon exposure.
Toxic to aquatic life with long-lasting effects, requiring careful handling and disposal.
Not for oral or systemic use; safety data emphasize precautions to avoid inhalation, ingestion, or skin contact.
Common erythromycin side effects (when used clinically) include nausea, vomiting, abdominal pain, and rare serious effects such as hepatotoxicity and cardiac arrhythmias, but these relate to erythromycin base or other formulations, not specifically the thiocyanate salt.

Routes of Administration

Erythromycin thiocyanate is supplied as a powder for research use and is typically dissolved for in vitro applications.
It is not approved or intended for direct human or veterinary administration.

Pharmacokinetics

Pharmacokinetic data specific to erythromycin thiocyanate are limited, as it is primarily a research chemical.
Erythromycin itself is rapidly absorbed orally (when given as suitable formulations), widely distributed in tissues, metabolized in the liver, and excreted mainly via bile and urine.
The thiocyanate salt form is mainly used for stability and solubility in laboratory settings rather than systemic use.

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