High quality Terbinafine Hydrochloride

Terbinafine hydrochloride is an acrylamide dermatologic broad-spectrum antifungal drug. It can specifically disturb the late biological decomposition of fungal sterols, selectively inhibit the activity of squalene epoxidase of fungi, and block the squalene epoxidation reaction in the process of fungal cell membrane constitution, so as to achieve the effect of killing or inhibiting fungi. It is suitable for the treatment of skin candidiasis, such as tinea cruris, tinea pedis, tinea cruris, tinea corporis and tinea pedis, and it is also the best medicine for treating gray nails.

Terbinafine Hydrochloride is a synthetic allylamine antifungal medication primarily used to treat fungal infections of the skin, nails, scalp, groin, and feet, including conditions like athlete's foot, jock itch, fungal nail infections, and pityriasis versicolor

Mechanism of Action

Terbinafine works by inhibiting the fungal enzyme squalene epoxidase (also called squalene monooxygenase), which catalyzes the conversion of squalene to lanosterol, a key step in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membranes. Inhibition leads to accumulation of squalene, which is toxic to fungal cells, and depletion of ergosterol, disrupting the fungal cell membrane and causing fungal cell death. This mechanism is selective for fungi because the fungal squalene epoxidase differs sufficiently from the human enzyme, so cholesterol synthesis in humans is not significantly affected.

Application

Treatment of dermatophyte infections such as onychomycosis (fungal nail infections)
Tinea infections of the skin including tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis
Pityriasis versicolor caused by Malassezia species.

Routes of Administration

Terbinafine hydrochloride is primarily administered orally in tablet or granule form. Oral granules should be taken with food and can be sprinkled on nonacidic soft foods like pudding or mashed potatoes. Topical formulations are also available but oral administration is common for nail and extensive skin infections.

Safety and Side Effects

Common side effects include headache, diarrhea, upset stomach, and itching. Serious but less common adverse effects include:
Severe allergic reactions such as DRESS syndrome affecting multiple organs
Blood disorders like lymphopenia and neutropenia increasing infection risk
Severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis, which can be fatal
Potential liver damage, sometimes severe enough to require liver transplant or cause death; symptoms include jaundice, dark urine, nausea, and abdominal pain
Changes in taste or smell, including loss of smell.
Patients should seek immediate medical attention if they experience symptoms of serious allergic reactions, severe skin reactions, or liver dysfunction.

Our company, Jianyan E-commerce Trading House in Yiwu City, is an innovative company mainly engaged in the research and development, production and sales of pharmaceutical intermediates and fine chemicals. The products are mainly used in the fields of medicine, health products, cosmetics, pesticides and electronic chemistry.
  We have a research and development centre and a production base. The R&D centre has advanced organic synthesis and analytical testing equipment. At the production base, we have large reaction vessels, including various specifications of stainless steel reaction vessels and enamel reaction vessels, capable of high-pressure,high-temperature and low-temperature reactions, with production capacities ranging from kilograms to tonnes. The company has established a comprehensive marketing network and its products are exported to countries and regions such as the United States, South Korea, Japan, India and Europe.

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FAQ
1. I did not find what I was looking for. Do you provide specific pack sizes or different packaging?

We are all about finding or creating the right solution for you. Our team is ready to work with you to meet your specific needs, even for small quantities. Please contact us.

2. Can I buy samples?

Please feel free to contact us.

3.What is your lead time?

It depends on the proudct and order quantity. Please contact us.

4. How can I get a price?

After we get your inquiry, we usually quote within 24 hours.

5. How to confirm the quality before placing the order？

You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.

7. Do you provide COA?

Yes. We'll provide certificate of analysis before shipment