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High quality Cinacalcet hydrochloride 364782-34-3

Name: High quality Cinacalcet hydrochloride 364782-34-3
Brand: HyperChem
SKU: pr2507111051
Price: 1909.7 USD
Availability: InStock

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CAS No.:

364782-34-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Sample Available:

Yes

Price valid (until):

2025-08-11

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Details
Seller Information

Description

Name	Cinacalcet hydrochloride
CAS number	364782-34-3
Description	Parathyroid hormone hydrochloride is a new compound used to treat hyperparathyroidism.
Molecular formula
Molecular Formula	C22H23ClF3N
Molecular Weight	393.88 g/mol
Appearance	white crystalline powder
Quality Standard	99%
Storage Condition	Inert atmosphere,2-8°C.
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Cinacalcet hydrochloride More Info

Cinacalcet hydrochloride is a calcimimetic agent that modulates calcium-sensing receptors (CaSR) to regulate parathyroid hormone (PTH) secretion. It is primarily used to treat secondary hyperparathyroidism in chronic kidney disease (CKD) patients on dialysis and hypercalcemia in parathyroid carcinoma. Marketed under the brand name Sensipar® (US) / Mimpara® (EU), it is administered orally as a film-coated tablet.

Manufacturing Process & Quality Control

Cinacalcet hydrochloride is synthesized through multi-step organic synthesis, starting from. Key steps include chiral resolution, amide coupling, and salt formation. Production follows cGMP guidelines, with strict control over impurities (e.g., genotoxic intermediates). Analytical methods (HPLC, NMR) ensure ≥99% purity, and stability studies confirm shelf-life under recommended storage conditions.

Therapeutic Applications & Pharmacokinetics

Clinically, cinacalcet reduces PTH, calcium, and phosphorus levels in CKD patients, lowering bone metabolism complications. It exhibits dose-dependent absorption, with food affecting bioavailability. Metabolism occurs via CYP3A4, requiring caution with concomitant CYP inhibitors/inducers. Adverse effects (nausea, hypocalcemia) necessitate regular serum calcium monitoring.

Regulatory & Safety Considerations

Cinacalcet carries boxed warnings for hypocalcemia and requires monitoring in dialysis patients. Contraindications include hypersensitivity and severe hepatic impairment. Environmental risk assessments address API disposal due to aquatic toxicity. Global regulations (FDA, EMA) mandate post-marketing surveillance for long-term safety data.

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Cinacalcet hydrochloride is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Cinacalcet hydrochloride is a hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride. It has a role as a calcimimetic and a P450 inhibitor. It derives from a cinacalcet.|Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.

Certificates

Basic Info

Product Name:

Cinacalcet hydrochloride

Other Name:

1-Naphthalenemethanamine,α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-,hydrochloride (1:1),(αR)-;1-Naphthalenemethanamine,α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-,hydrochloride,(αR)-;AMG 073 HCl;Cinacalcet hydrochloride;KRN 1493;Sensipar;Mimpara;Regpara;N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride;[(1R)-1-(Naphthalen-1-yl)ethyl]([3-[3-(trifluoromethyl)phenyl]propyl])amine hydrochloride

CAS No.:

364782-34-3

Molecular Formula:

C22H22F3N.ClH

InChIKeys:

InChIKey=QANQWUQOEJZMLL-PKLMIRHRSA-N

Molecular Weight:

393.88

Exact Mass:

393.147125

EC Number:

1308068-626-2

UNII:

1K860WSG25

DSSTox ID:

DTXSID3046792

NCI Thesaurus Code:

C47450

ATC Code:

H05BX01

HScode:

2921499090

Categories:

Antibiotics

Characteristics

PSA:

XLogP3:

7.33490

Appearance:

Off-White to Tan Solid

Melting Point:

180-184 °C

Boiling Point:

440.9ºCat760mmHg

Flash Point:

220.5ºC

Water Solubility:

In water, 9.2X10-2 mg/L at 25 deg C /Estimated/

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.5X10-7 mm Hg at 25 deg C at 25 deg C /Estimated/

See More Cinacalcet hydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Skin sensitization, Category 1

Serious eye damage, Category 1

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H317 May cause an allergic skin reaction H318 Causes serious eye damage H373 May cause damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P317 If skin irritation or rash occurs: Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Cinacalcet hydrochloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.
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High quality Cinacalcet hydrochloride 364782-34-3

Product Details

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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