Name | Phosphatidylserine |
CAS number | 51446-62-9 |
Description | Phosphatidylserine (PS) is a phospholipid and a fundamental component of cell membranes, particularly concentrated in the inner leaflet of the plasma membrane in mammalian cells. |
Structural formula | |
Molecular Formula | C42H82NO10P |
Molecular Weight | 749.07 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Phosphatidylserine More Info
Phosphatidylserine (PS) is a phospholipid and a fundamental component of cell membranes, particularly concentrated in the inner leaflet of the plasma membrane in mammalian cells. It plays a critical role in key cellular processes, including apoptosis (programmed cell death), signal transduction, and maintaining membrane integrity. Historically, commercial PS was derived from bovine brain cortex; however, due to concerns about transmissible spongiform encephalopathies (e.g., Mad Cow Disease), modern production exclusively utilizes plant-based sources. The most common method involves the enzymatic conversion of phosphatidylcholine derived from soy or sunflower lecithin, where the polar head group is swapped for serine in a process called transphosphatidylation. This shift to plant-sourced PS has ensured a safe and scalable supply for commercial use.
Uses and Applications
The primary application of Phosphatidylserine is in the dietary supplement and functional food industry, where it is marketed for its role in supporting cognitive health. It is extensively used in formulations aimed at improving memory, focus, and cognitive function in both aging adults and younger individuals, with numerous studies investigating its potential to support brain health under stress. Beyond cognitive supplements, it is a key ingredient in sports nutrition products for its purported ability to reduce exercise-induced cortisol levels, potentially aiding recovery. Furthermore, it finds application in liposomal drug delivery systems due to its ability to form stable lipid bilayers, enhancing the bioavailability of certain active compounds.
Application Market
The market for Phosphatidylserine is a robust and growing segment within the global nutraceutical and cognitive health ingredients market. Demand is driven by an aging population concerned about maintaining cognitive function, as well as by students and professionals seeking nootropic ("smart drug") supplements. The market is also expanding in the sports nutrition sector. It is positioned as a premium, science-backed ingredient, with sunflower-derived PS often marketed as a non-GMO, allergen-free (non-soy) alternative at a higher price point. The market is global, with significant consumption in North America, Europe, and Asia, and is supplied by specialized ingredient manufacturers who provide it in bulk powder or encapsulated forms to supplement brands.
Important Considerations
Phosphatidylserine derived from soy or sunflower is generally recognized as safe (GRAS) for consumption by regulatory bodies like the FDA. However, appropriate usage guidelines must be followed. While generally well-tolerated, high doses may cause mild gastrointestinal effects such as bloating or insomnia in some individuals. It is crucial for manufacturers and consumers to ensure the product is plant-sourced, as bovine-derived PS is no longer used due to safety concerns. In an industrial setting, handling the powder requires standard good manufacturing practices to prevent contamination. All health claims must be compliant with regional regulations, typically falling under structure/function claims for dietary supplements rather than approved drug claims for treating diseases. Consumers with soy allergies should opt for sunflower-derived PS.
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