Isoamyl nitrite cas 110-46-3 yellow liquid

A pale yellow clear liquid with an ether-like odor and a fruity fragrance. It can volatilize at room temperature and is flammable. It is almost insoluble in water and can be mixed with ethanol, ether, chloroform or benzene freely. It decomposes upon exposure to light and air. Isopropyl nitrite, also known as isopropyl nitrate or nitric oxide nitrate, is an anti-anginal drug with the fastest onset and the shortest duration of action. It belongs to the short-acting vasodilator of the nitrosoester class. Its pharmacological effect is similar to that of nitroglycerin, directly relaxing the smooth muscle of blood vessels, especially that of small blood vessels, causing systemic vasodilation, reducing peripheral resistance, lowering blood pressure, reducing venous return, decreasing cardiac output, thereby reducing myocardial oxygen consumption and alleviating angina pectoris. It also effectively stimulates sexual desire. Due to its rapid hydrolysis in the gastrointestinal tract, this product is ineffective when taken orally. Usually, the drugs used in clinical practice are made into volatile liquid inhalants by pharmaceutical factories, which are rapidly absorbed in the lungs after inhalation and take effect within less than half a minute, with the effect lasting for 3 to 10 minutes. Its anti-anginal effect is similar to that of nitroglycerin, but the inhalation dosage of this product is difficult to control and the adverse reactions are relatively large, which are its disadvantages. Due to its frequent occurrence of severe headache, severe hypotension and tachycardia, it is rarely used for clinical treatment of angina pectoris and biliary colic, and has gradually been replaced by other nitrosoester drugs. [Precautions and Adverse Reactions] Common adverse reactions include headache, facial flushing, hypotension and reflex tachycardia. The reaction of isopropyl nitrite is more severe than that of nitroglycerin. Taking excessive dosage can cause hypotension and increased heart rate, aggravating angina pectoris symptoms. During intravenous infusion, close observation of heart rate and blood pressure is necessary. Due to the production of excessive poisoning， symptoms include cyanosis， breathing difficulties and other hypoxia symptoms. Intravenous injection of 1% methylene blue can be used for emergency treatment， while oxygen inhalation and blood transfusion should also be provided. Those with head trauma， cerebral hemorrhage， acute coronary artery embolism should be prohibited from using it. Those with coronary artery occlusion and increased intracranial pressure should also be prohibited from using it.

A light yellow clear liquid with a boiling point of 99℃, a relative density of 0.871 (20/4℃), a refractive index of 1.3871, and a flash point of 10℃. It can be mixed with alcohols and ethers, but does not dissolve in water. It has a fruity aroma. It is volatile and will decompose upon exposure to light and air. It is used in the synthesis of fragrances, drugs, and diazonium compounds. It can be used as an oxidant and solvent. Isobutyronitrile is a drug, being the fastest-acting short-acting vasodilator of the nitroso ester class. It can also be used as an antidote for hydrogen cyanide and its salts poisoning.Used in the synthesis of spices, drugs, and diazonium compounds. Can be used as an oxidant and solvent. Nitroisobutyrate is a drug, being the fastest-acting short-acting vasodilator among nitroester drugs. It can also be used as an antidote for hydrogen cyanide acid and its salts poisoning; a vasodilator drug, used to treat angina pectoris, and also for cyanide poisoning; used in the synthesis of spices, drugs and diazonium compounds, and also as an oxidant and solvent.