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Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.

Name: Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.
Brand: Tianrui
SKU: pr2511121338
Price: 10 USD
Availability: InStock

5 Inquiries

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CAS No.:

162401-32-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Qingdao

Brand:

Tianrui

Packaging:

Sealed fiber drum

Price valid (until):

2025-11-12

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Hefei Tianrui Pharmaceutical Chemical Co., Ltd.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

APIs

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Product Description
Seller Information
Inquiry History

Description

About Product

Roflumilast (CAS: 162401-32-3) is a high-purity active pharmaceutical ingredient (API) that functions as a selective phosphodiesterase-4 (PDE4) inhibitor. It is specifically developed for the maintenance treatment of chronic obstructive pulmonary disease (COPD) to reduce the risk of exacerbations. Manufactured by Hefei TianRui Pharmaceutical under cGMP conditions, our Roflumilast API guarantees high purity, excellent stability, and reliable quality for respiratory drug formulations.

Items	Specifications
Product Name	Roflumilast
CAS Registry Number	162401-32-3
IUPAC Name	3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Molecular Weight	403.21 g/mol
Solubility	Insoluble in water; readily soluble in dimethyl sulfoxide; slightly soluble in methanol.
Melting Point	160-163°C
Primary Use	For the maintenance treatment of chronic obstructive pulmonary disease (COPD), to reduce acute exacerbations

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Company Profile

Founded: 2014
Focus: High-tech enterprise specializing in the development and industrialization of small-molecule pharmaceutical synthesis technology
Facilities:
- Two workshops (TR1 & TR2) with total capacity ≈ 1000 tons/year
- Reactors: 3000L×15, 2000L×10, and numerous smaller reactors (1000L, 500L, 100L)
- Ultra-low temperature cryogenic reactor (explosion-proof workshop included)
- GMP workshop & clean room
QC Lab Equipment: GC×2, HPLC×3, UV, IR, KF titrator, etc.

About company

Shop Roflumilast API - A Selective PDE4 Inhibitor for COPD Maintenance Treatment.-Detailed Image 7

In 2015, the company developed polypeptide absorbent permeation enhancers: ethyl 8-bromo-octanoate and Carsalam, which is the 1st and only qualified Chinese supplier of Semaglutide to meet the internal control requirements of innovator Novo Nordisk.

In 2020, the company independently developed and optimized 8-bromo-octanoic acid and 6-bromo-caproic acid to become a COVID-19 vaccine carrier manufacturer and supplier to Moderna company, contributing its share to the fight against COVID-19.

In 2022, Tianrui R&D Center and cGMP manufacturing facility was inaugurated and put into operation. And in the same year, polypeptide absorbent permeation enhancers SNAC (Salcaprozate Sodium) has successfully obtained the domestic CDE registration number (F20220000072) and the US FDA registration number (037135), and another batch of innovative APIs and pharmaceutical excipients are under registration and approval.

Basic Info

Product Name:

Roflumilast

Other Name:

Benzamide,3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;Roflumilast;BYK 20869;BY 217;B 9302-107;Daxas;Daliresp;ARQ 151;Libertek

CAS No.:

162401-32-3

Molecular Formula:

C17H14Cl2F2N2O3

InChIKeys:

InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N

Molecular Weight:

403.21

Exact Mass:

403.21

EC Number:

223-583-8

UNII:

0P6C6ZOP5U

DSSTox ID:

DTXSID8044123

NCI Thesaurus Code:

C76890

ATC Code:

R03DX07|R03DX08|R - Respiratory system

Categories:

Dermatological Agents

Characteristics

PSA:

60.4

XLogP3:

4.6

Appearance:

white to beige

Density:

1.471±0.06 g/cm3(Predicted)

Melting Point:

157-157.5 °C

Boiling Point:

430.6±45.0 °C(Predicted)

Flash Point:

214.2±28.7 °C

Refractive Index:

1.604

Water Solubility:

H2O: 0.52-0.56 mg/L at 22°C);DMSO: soluble 20mg/mL, clear

Storage Conditions:

Refrigerator

Vapor Pressure:

1.28E-07mmHg at 25°C

PKA:

8.74None

Dissociation Constants:

8.74

See More Roflumilast Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Roflumilast Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
APIs

Location:
No.23,lntersection of Fenglehe Avenue and Leiyang Road, Huagang Town,Feixi County, Hefei, Anhui, China.

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$50 million-$100 million

Total Employees:
11-50

Year of Establishment:
2014

About TianRui

Hefei TianRui Pharmaceutical Chemical Co., Ltd was founded in 2014 as a high-tech enterprise focused on the development and industrialization of pharmaceutical small molecule synthesis technology. Our workshop and R&D center are located in Hefei HuaGang Provincial Industrial Park, Anhui Province. We are committed to providing professional technical services and commercialization of small molecule specialty APIs, CGMP standard intermediates, and functional pharmaceutical excipients and MRNA vaccine vectors for domestic and overseas well-known pharmaceutical companies.

Main Events

In 2015, the company developed polypeptide absorbent permeation enhancers: ethyl 8-bromo-octanoate and Carsalam, which is the 1st and only qualified Chinese supplier of Semaglutide to meet the internal control requirements of innovator Novo Nordisk.

In 2020, the company independently developed and optimized 8-bromo-octanoic acid and 6-bromo-caproic acid to become a COVID-19 vaccine carrier manufacturer and supplier to Moderna company, contributing its share to the fight against COVID-19.

In 2022, Tianrui R&D Center and cGMP manufacturing facility was inaugurated and put into operation. And in the same year, polypeptide absorbent permeation enhancers SNAC (Salcaprozate Sodium) has successfully obtained the domestic CDE registration number (F20220000072) and the US FDA registration number (037135), and another batch of innovative APIs and pharmaceutical excipients are under registration and approval.

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Roflumilast	1 G	Jul 29, 2025
United States	Roflumilast	10 G	Jun 5, 2026
United States	Roflumilast	10 G	May 9, 2026
United Kingdom	Roflumilast	10 G	Jul 29, 2025
India	Roflumilast	6	Jan 29, 2024

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