N-Acetyl Selank Amidate 99% Purity CAS 129954-34-3 Finished for Potency Muscle Gain Fat Loss Cognitive Enhancement 5-20mg Vials

1.  Description

      Chemical Properties: Selank is a linear heptapeptide compound with core functional groups comprising peptide bonds, amino groups, and carboxyl groups. As a corticotropin-releasing factor (CRF) receptor antagonist, it specifically blocks CRF-mediated anxiety signaling pathways without exhibiting receptor-binding characteristics of benzodiazepine drugs. Chemically stable, it resists peptidase hydrolysis in neutral to weakly acidic environments (pH 5.0–7.0). Its half-life is 3–4 times longer than that of natural thymosin fragments, and it exhibits excellent compatibility with neurotrophic components such as B vitamins and phosphatidylserine.

      Physical Properties: Selank appears as a white to off-white crystalline powder at room temperature, odorless and tasteless. It exhibits excellent water solubility (solubility ≥60 mg/mL), dissolving rapidly in aqueous systems such as pure water, physiological saline, and phosphate-buffered saline (PBS). It is slightly soluble in ethanol and propylene glycol but insoluble in nonpolar solvents like ether and petroleum ether. Store at 2-8°C in a dry, sealed container protected from light; avoid repeated freeze-thaw cycles. Both research-grade and application-grade products exhibit ≥98% purity (HPLC-detected), ≤1.0% impurity, and no endotoxin residue.

     Source and Preparation: Selank has no natural occurrence and is precisely synthesized via solid-phase peptide synthesis. Using high-purity L-type amino acids as raw materials, the target sequence is constructed through multiple reactions including condensation, deprotection, and peptide chain assembly. The final high-purity product is obtained via high-performance liquid chromatography (HPLC) purification. The synthesis process strictly controls reaction temperature (25-30°C) and feed ratios to ensure peptide chain structural integrity and neuromodulatory activity.

2.  Application

     Biomedical Research Field: Selank serves as a core tool reagent for studying neuromodulatory mechanisms, applied in investigating the pathophysiology of anxiety disorders, cognitive decline, post-traumatic stress disorder (PTSD), and neurodegenerative diseases (such as mild cognitive impairment, MCI). Through animal models like rats and mice, as well as in vitro models of neural cells (e.g., hippocampal neurons), it analyzes its regulatory effects on the CRF pathway and brain-derived neurotrophic factor (BDNF) expression, providing experimental evidence for neuropharmacological drug development.

     High-End Functional Supplement Sector: As a neurohealth ingredient, Selank is used to develop dietary supplements including capsules, freeze-dried powders, and sublingual tablets. It targets: - High-pressure professionals (alleviating anxiety and mental fatigue) - Middle-aged and elderly individuals (improving mild cognitive decline) - Exam candidates/high-intensity cognitive users (enhancing attention and memory). Its small-molecule structure (molecular weight 751.9 Da) enables blood-brain barrier penetration (approximately 12% permeability) and absorption without digestive breakdown, meeting EU and US dietary supplement compliance standards.

     Potential Skin Repair and Aesthetic Medicine Applications: Leveraging its anti-inflammatory and immunomodulatory properties, Selank can be incorporated into post-aesthetic procedure repair products (e.g., post-photorejuvenation or microneedling serums/creams) to alleviate post-treatment redness and inflammatory reactions. It may also be used in sensitive skin repair formulations, where it modulates the skin's neuro-immune pathway to improve redness and itching caused by neurogenic inflammation. These applications are currently in the preclinical validation phase.

3. Main Efficacy

        Anxiolytic and Mood-Regulating Effects: The core mechanism involves competitively binding to CRF1 receptors in the central nervous system, blocking CRF-mediated anxiety signaling while simultaneously upregulating gamma-aminobutyric acid (GABA) release in the hippocampus to balance neural excitability. Animal studies demonstrate that Selank significantly reduces anxiety scores in elevated plus maze tests among anxiety-modeled mice, without the sedation or drowsiness side effects of benzodiazepines, nor addictive properties or withdrawal symptoms.

     Cognitive Enhancement and Neuroprotection: By promoting brain-derived neurotrophic factor (BDNF) expression, it activates hippocampal neuron proliferation and synaptic plasticity, improving learning, memory, attention, and information processing speed. Simultaneously, it scavenges reactive oxygen species (ROS) within neurons, inhibits neuronal apoptosis, and protects hippocampal neurons from oxidative stress and glutamate excitotoxicity damage. It demonstrates efficacy in improving cognitive decline associated with aging or mild brain injury.

     Anti-inflammatory and Immunomodulatory Effects: Inhibits release of pro-inflammatory factors (e.g., TNF-α, IL-6) in peripheral and central systems, regulates monocyte and lymphocyte activity, and balances immune responses; At the skin level, it suppresses neurogenic inflammation (e.g., CGRP-mediated erythema), repairs the skin neuro-immune barrier, alleviates recurrent redness and stinging in sensitive skin, and reduces post-aesthetic procedure inflammation resolution time by over 25%.

     Safety Advantages: No cytotoxicity (MTT assay shows >97% nerve cell survival at concentrations ≤2 mg/mL), no mutagenicity, no reproductive toxicity, and no significant adverse reactions with long-term low-dose use. Compared to traditional anti-anxiety medications, it does not impair motor coordination or cognitive clarity, making it suitable for daily, long-term use.