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4-Bromoaniline CAS:106-40-1

Name: 4-Bromoaniline CAS:106-40-1
Brand: Orient
SKU: pr2511261308
Price: 2 USD
Availability: InStock

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CAS No.:

106-40-1

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

4-Bromoaniline Basic information

Product Name:	4-Bromoaniline
Synonyms:	4-Bromanilinu;4-bromanilinu(czech);4-bromo-benzenamin;AKOS BBS-00003662;4-BROMOBENZENAMIDE;4-BROMOBENZENAMINE;4-BROMOANILINE;4-Bromoanilines
CAS:	106-40-1
MF:	C6H6BrN
MW:	172.02
EINECS:	203-393-9
Product Categories:	C2 to C6;Nitrogen Compounds;Anilines, Amides & Amines;Bromine Compounds;Anilines (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Phenyls & Phenyl-Het;amine \| alkyl bromide;FINE Chemical & INTERMEDIATES;Anilines, Aromatic Amines and Nitro Compounds;Amines;Phenyls & Phenyl-Het;API intermediates;106-40-1
Mol File:	106-40-1.mol

4-Bromoaniline Chemical Properties

Melting point	56-62 °C (lit.)
Boiling point	230-250 °C
bulk density	810kg/m3
density	1.497
refractive index	1.5680 (estimate)
Fp	222-224°C
storage temp.	Store below +30°C.
solubility	ethanol: soluble0.5g/10 mL, clear, colorless to almost colorless
pka	3.86(at 25℃)
form	crystalline
color	white to light yellow
Odor	Sweetish
Water Solubility	<0.1 g/100 mL at 23 ºC
Merck	14,1404
BRN	742031
Dielectric constant	13.0（-7℃）
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, peroxides, acids, acid chlorides, acid anhydrides, chloroformates. May be air sensitive.
InChIKey	WDFQBORIUYODSI-UHFFFAOYSA-N
CAS DataBase Reference	106-40-1(CAS DataBase Reference)
NIST Chemistry Reference	4-Bromoaniline(106-40-1)
EPA Substance Registry System	p-Bromoaniline (106-40-1)

Safety Information

Hazard Codes	Xn
Risk Statements	21/22-36/37/38-20/21/22
Safety Statements	26-36/37-36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	BW9280000
F	8-9-23
Hazard Note	Harmful
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214210
Hazardous Substances Data	106-40-1(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 456 mg/kg LD50 dermal Rat 536 mg/kg

4-Bromoaniline Usage And Synthesis

Chemical Properties	Gray-brown crystals with a peculiar odor. When heated or burned, they break down and release harmful fumes that contain hydrogen bromide and nitrogen oxides. When dissolved in water, it acts as a mild base. It reacts with acids and powerful oxidizing agents. The compound 4-bromoaniline consists of a hydrophobic benzene ring and an amino group that assists in carrying substances and improving PSC stability.
Uses	4-Bromoaniline is a brominated aniline that is commonly used as a building block in the preparation of pharmaceutical and organic compounds. It is used in the preparation of azo dyes and is condensed with formaldehyde to prepare dihydroquinazolines. In addition, 4-Bromoaniline is also used as an intermediate in the production of other chemicals such as metobromuron, a herbicide, and resorantel, an antiparasitic agent.
Preparation	4-bromoaniline can be made by reacting aniline with bromine with a protection with acetyl chloride.
Synthesis Reference(s)	The Journal of Organic Chemistry, 40, p. 1867, 1975 DOI: 10.1021/jo00900a053 Synthetic Communications, 19, p. 3047, 1989 DOI: 10.1080/00397918908052699
General Description	P-bromoaniline is a brown solid with a sweet odor. (NTP, 1992)
Air & Water Reactions	4-Bromoaniline is sensitive to prolonged exposure to air. Vapor may form highly reactive mixtures in air . Insoluble in water.
Reactivity Profile	Vapor may form highly reactive mixtures in air.
Fire Hazard	Flash point data are not available for 4-Bromoaniline, but 4-Bromoaniline is probably combustible.
Biological Activity	4-Bromoaniline reduces gluconeogenesis in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.
Synthesis	RGO/Cu NPs (25 mg), arylboronic acid (1.0 mmol), K2CO3(1.3 mmol), 25-28% aqueous ammonia (5 mmol) and methanol(4 mL) were added to a 50 mL round-bottomed flask. The reactionmixture was stirred under reflux conditions for the appropriatetime. After completion of the reaction as monitored by TLC, themixture was filtered, and the solvent of the filtrate was removedunder vacuum with the aid of a rotary evaporator. The residue waspurified by column chromatography on silica gel to afford 4-Bromoaniline.
Purification Methods	Crystallise the aniline (with appreciable loss) from aqueous EtOH. The benzoyl derivative has m 204o (from EtOH). [Beilstein 12 IV 1497.]

4-Bromoaniline Preparation Products And Raw materials

Raw materials

4-Nitroaniline-->Hydrochloric acid-->Copper(II) sulfate-->Cuprous bromide-->1-Bromo-4-nitrobenzene-->Hydrogen bromide-->Sodium nitrite-->4-Bromophenylboronic acid-->1-Bromo-4-iodobenzene-->Aniline

Preparation Products

4-BROMO-2-NITROPHENYLBORONIC ACID-->6-BROMO-4-CHLOROQUINOLINE-->4-Aminobiphenyl-->6-Bromoquinoline-->6-bromoquinolin-4(3H)-one-->4-(4-Methylpiperazin-1-yl)phenylboronic Acid-->brotianide-->4-Bromobiphenyl-->2-(4-BROMOPHENYL)THIOPHENE-->4-BROMOPHENYLTHIOUREA-->4-Aminophenylboronic acid pinacol ester-->2-Amino-6-bromobenzothiazole-->4-BROMOPHENYLUREA-->4'-Bromoacetanilide-->5-(4-Bromophenyl)furfural-->polyaniline synthesized by means of condensation polymerization-->4,4'-THIODIANILINE-->Diazene, (4-bromophenyl)(4-chlorophenyl)- (9CI)-->ethenylsulfanylethene

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

4-Bromoaniline

Other Name:

Benzenamine,4-bromo-;Aniline,p-bromo-;4-Bromobenzenamine;p-Bromoaniline;4-Bromoaniline;p-Bromophenylamine;1-Amino-4-bromobenzene;p-Aminobromobenzene;4-Bromophenylamine;NSC 7085;4-Aminobromobenzene;p-Aminophenyl bromide

CAS No.:

106-40-1

Molecular Formula:

C6H6BrN

InChIKeys:

InChIKey=WDFQBORIUYODSI-UHFFFAOYSA-N

Molecular Weight:

172.02

Exact Mass:

172.02

BRN:

742031

EC Number:

203-393-9

UNII:

0RR61TC330

ICSC Number:

1226

NSC Number:

7085

UN Number:

2811

DSSTox ID:

DTXSID7021867

Color/Form:

Bipyramidal rhombic crystals, needles from 60% alcohol|Colorless crystals

HScode:

29214210

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

2.26

Appearance:

white to light yellow crystalline

Density:

1.4970 g/cm³ @ Temp: 99.6 °C

Melting Point:

66-66.5 °C

Boiling Point:

230-250 °C

Flash Point:

222-224°C

Refractive Index:

1.5680 (estimate)

Water Solubility:

H2O: <0.1 g/100 mL at 23 ºC;ethanol: soluble 0.5g/10 mL, clear, colorless to almost colorless

Storage Conditions:

Store below +30°C.

Vapor Pressure:

Vapour pressure, Pa at 25°C: 22.6

Vapor Density:

Relative vapour density (air = 1): 5.9

Toxicity:

Oral-rat LD50: 456 mg/kg; Oral-Mouse LD50: 289 mg/kg

Flammability characteristics:

Combustible in case of open fire; burning releases toxic nitrogen oxides and bromide fumes

Henrys Law Constant:

Henry's Law constant = 9.1X10-7 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 3.86 at 25 °C (conjugate acid)|Dissociation constant pKb = 10.28 at 25 °C (also reported as 9.98)

Experimental Properties:

Aqueous solutions of 4-bromoaniline are slightly alkaline|UV: 6-68 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York) /3-Bromoaniline/

Air and Water Reactions:

This material is sensitive to prolonged exposure to air. Vapor may form highly reactive mixtures in air (NTP, 1992). Insoluble in water.

Reactive Group:

Aryl Halides

Reactivity Profile:

Vapor may form highly reactive mixtures in air. (NTP, 1992)

See More 4-Bromoaniline Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 3, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and acids. Well closed.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Store under inert gas. Air sensitive.

See More 4-Bromoaniline Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

7 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	4 Bromo Aniline	1500.00 KG	Jun 13, 2024
India	4- bromo aniline	50.00 KG	Jun 24, 2024
India	4-Bromo Aniline	1 KG	Sep 17, 2025
India	Para BROMO aniline	2 MT	Dec 11, 2023
India	Vinylidene chloride	500.00 KG	Jun 13, 2024
India	Meta Chloro Per Benzoic Acid	2.00 MT	Jun 13, 2024
India	Boc L- Alanine	10.00 KG	Jun 13, 2024

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