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CORTEXOLONE 152-58-9

Name: CORTEXOLONE 152-58-9
Brand: Orient
SKU: pr2512271007
Price: 4 USD
Availability: InStock

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CAS No.:

152-58-9

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-27

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	CORTEXOLONE
Synonyms:	(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one;Hydrocortisone Impurity 6（Hydrocortisone EP Impurity F）;11-DEOXYCORTISOL; CORTEXOLONE; REICHSTEIN'S SUBSTANCE S;11-dioxy-cortiso;11-dioxycortisol;17,21-dihydroxy-pregn-4-ene-20-dione;17-hydroxy-11-deoxycorticosterone;nsc-18317
CAS:	152-58-9
MF:	C21H30O4
MW:	346.46
EINECS:	205-805-2
Product Categories:	Inhibitors;Intermediates & Fine Chemicals;Steroids;Biochemistry;Hydroxyketosteroids;Pharmaceuticals;Pharmaceutical Raw Materials;152-58-9;1
Mol File:	152-58-9.mol

CORTEXOLONE Chemical Properties

Melting point	205-208 °C
Boiling point	401.19°C (rough estimate)
density	1.22±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	120 ° (C=1, Dioxane)
Fp	9℃
storage temp.	Sealed in dry,Room Temperature
solubility	Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
pka	12?+-.0.60(Predicted)
form	Solid
color	White to Off-White
Water Solubility	44.08mg/L(37 ºC)
Merck	14,2932
InChI	InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
InChIKey	WHBHBVVOGNECLV-OBQKJFGGSA-N
SMILES	C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](O)(C(=O)CO)CC3)CC2
CAS DataBase Reference	152-58-9(CAS DataBase Reference)

Safety Information

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	24/25-22-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	TU5011500
HS Code	2937.23.5050
Toxicity	mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,

MSDS Information

CORTEXOLONE Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.

Definition

ChEBI: 11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a glucocorticoid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a deoxycortisol.

in vivo

Cortodoxone (100 mg/kg; i.p.) increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone^[1].

Animal Model:	220-320g, adult male Wistar rats^[2]
Dosage:	100 mg/kg
Administration:	IP
Result:	Increased tryptophan oxygenase (TO) activity and induced the secretion of corticosterone.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

11-Deoxycortisol

Other Name:

Pregn-4-ene-3,20-dione,17,21-dihydroxy-;Compound S;17,21-Dihydroxypregn-4-ene-3,20-dione;Cortexolone;Cortisol,11-deoxy-;Cortodoxone;11-Deoxycortisol;11-Deoxyhydrocortisone;11-Desoxyhydrocortisone;17α,21-Dihydroxypregn-4-ene-3,20-dione;17α-Hydroxycortexone;17-Hydroxy-11-deoxycorticosterone;Δ4-Pregnene-17α,21-diol-3,20-dione;4-Pregnene-17α,21-diol-3,20-dione;Reichstein S;Reichstein's compound S;Reichstein's substance S;Substance S;17,21-Dihydroxyprogesterone;11-Deoxy-17-hydroxycorticosterone;11-Desoxycortisol;17α,21-Dihydroxyprogesterone;17,21-Dihydroxypregn-4-en-3,20-dione;4-Pregnen-17α,21-diol-3,20-dione;SKF 3050;11-Deoxycortisone;11-Desoxy-17α-hydroxycorticosterone;11-Deoxy-17-hydrocorticosterone;Cortifen;17α,21-Dihydroxy-4-pregnen-3,20-dione;NSC 18317;Reichstein substance S;4-Pregnene-11β,17,21-triol-3,20-dione;37-60-5;478614-16-3

CAS No.:

152-58-9

Molecular Formula:

C21H30O4

InChIKeys:

InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N

Molecular Weight:

346.46

Exact Mass:

346.46

EC Number:

205-805-2

UNII:

WDT5SLP0HQ

DSSTox ID:

DTXSID8045642

NCI Thesaurus Code:

C80813

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

74.6

XLogP3:

3.08

Appearance:

Solid

Density:

1.22±0.1 g/cm3 (20 ºC 760 Torr)

Melting Point:

215 °C

Boiling Point:

401.19°C (rough estimate)

Flash Point:

9℃

Refractive Index:

120 ° (C=1, Dioxane)

Storage Conditions:

-20°C Freezer

Vapor Pressure:

3.41E-13mmHg at 25°C

Collision Cross Section:

187.4 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|183.12 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|187.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|211 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|194 Å² [M-H]-|187.8 Å² [M+H]+

See More 11-Deoxycortisol Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 11-Deoxycortisol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	11-Deoxy Cortisol	10 G	Jun 12, 2025

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