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Trifluoroacetic anhydride CAS:407-25-0

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CAS No.:

407-25-0

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Items	Specifications
Product name	Trifluoroacetic anhydride
CAS	407-25-0
Appearance	LIQUID
Uses	Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical. Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Preparation	Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
reaction suitability	reagent type: derivatization reagent reaction type: Acylations reagent type: derivatization reagent reaction type: Esterifications
Safety Profile	A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods	Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Chemical Properties

Melting point	-65 °C (lit.)
Boiling point	39.5-40 °C (lit.)
density	1.511 g/mL at 20 °C (lit.)
vapor pressure	6.28 psi ( 20 °C)
refractive index	n20/D 1.3(lit.)
Fp	-26 °C
storage temp.	2-8°C
solubility	Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
pka	0.43[at 20 ℃]
form	Liquid
color	Clear
Specific Gravity	1.487
Water Solubility	Hydrolysis
Sensitive	Moisture Sensitive
BRN	746197
Stability:	Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
LogP	0.79 at 25℃
CAS DataBase Reference	407-25-0(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System	Acetic acid, trifluoro-, anhydride (407-25-0)

Safety Information

Hazard Codes	C,T
Risk Statements	14-20-35-52/53-34-23/24/25
Safety Statements	26-36/37/39-43-45-61-9-8-28A-27
RIDADR	UN 3265 8/PG 1
WGK Germany	2
RTECS	AJ9800000
F	3-10
Hazard Note	Corrosive/Moisture Sensitive
TSCA	T
HazardClass	8
PackingGroup	I
HS Code	29159080
Toxicity	skn-rbt 500 mg/24H SEV 28ZPAK -,91,72

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Trifluoroacetic anhydride

Other Name:

Acetic acid,2,2,2-trifluoro-,1,1′-anhydride;Acetic acid,trifluoro-,anhydride;Trifluoroacetic anhydride;Perfluoroacetic anhydride;Trifluoroacetic acid anhydride;Hexafluoroacetic anhydride;Trifluoroacetyl anhydride;Bis(trifluoroacetic) anhydride;2,2,2-Trifluoroacetic anhydride;NSC 96965;(2,2,2-Trifluoroacetyl) 2,2,2-trifluoroacetate

CAS No.:

407-25-0

Molecular Formula:

C4F6O3

InChIKeys:

InChIKey=QAEDZJGFFMLHHQ-UHFFFAOYSA-N

Molecular Weight:

210.03100

Exact Mass:

210.03

EC Number:

206-982-9

UNII:

5ENA87IZHT

NSC Number:

96965

HScode:

29159080

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

43.37000

XLogP3:

1.18080

Appearance:

Liquid

Density:

1.490 g/cm³ @ Temp: 25 °C

Melting Point:

-65 °C

Boiling Point:

39.5 °C

Flash Point:

-26ºC

Refractive Index:

1.269

Water Solubility:

Hydrolysis

Storage Conditions:

2-8ºC

Vapor Pressure:

6.28 psi ( 20 °C)

Toxicity:

skn-rbt 500 mg/24H SEV 28ZPAK -,91,72

See More Trifluoroacetic anhydride Properties 

Hazard Identification

Classification of the substance or mixture

Skin corrosion, Sub-category 1A

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H314 Causes severe skin burns and eye damage H332 Harmful if inhaled H412 Harmful to aquatic life with long lasting effects
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Trifluoroacetic anhydride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Trifluoroacetic Anhydride	10.00 KG	Aug 8, 2025
India	Trifluoroacetic anhydride	500 KG	Apr 30, 2025
Russia	Trifluoroacetic anhydride	50 KG	Aug 1, 2023

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