L-Glutamic acid 5-methyl ester 1499-55-4

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

L-Glutamic acid 5-methyl ester Basic information

Product Name:	L-Glutamic acid 5-methyl ester
Synonyms:	L-GlutaMic acid 5-Methyl ester, 95+%;L-Glutamic acid 5-methyl ester 99%;L-Glutamic acid γ-methyl ester≥ 98.5% (HPLC);Glu(Ome)-OH;(5)-methyl L-hydrogen glutamate;L-GUTAMIC ACID 5-METHYL ESTER 99%;L-Gutamic Acid 5-Methyl Ester;Mono-methyl-L-glutamate
CAS:	1499-55-4
MF:	C6H11NO4
MW:	161.16
EINECS:	216-110-9
Product Categories:	Pyrazoles;Glutamic acid [Glu, E];Amino Acids Derivatives;Amino Acids and Derivatives
Mol File:	1499-55-4.mol

L-Glutamic acid 5-methyl ester Chemical Properties

Melting point	182 °C (dec.) (lit.)
alpha	13 º (c=1, H2O 24 ºC)
Boiling point	287.44°C (rough estimate)
density	1.3482 (rough estimate)
refractive index	29 ° (C=2, 6mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Water Solubility	Soluble in water
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	2.18±0.10(Predicted)
form	powder to crystal
color	White to Almost white
Optical Rotation	[α]20/D +29°, c = 2 in 6 M HCl
BRN	1725252
InChI	InChI=1S/C6H11NO4/c1-11-5(8)3-2-4(7)6(9)10/h4H,2-3,7H2,1H3,(H,9,10)/t4-/m0/s1
InChIKey	ZGEYCCHDTIDZAE-BYPYZUCNSA-N
SMILES	C(O)(=O)[C@H](CCC(OC)=O)N
CAS DataBase Reference	1499-55-4(CAS DataBase Reference)

Safety Information

Safety Statements	24/25
WGK Germany	3
HS Code	29224999

MSDS Information

L-Glutamic acid 5-methyl ester Usage And Synthesis

Chemical Properties	white amorphous powder
Uses	L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).
Definition	ChEBI: L-glutamic acid 5-methyl ester is a glutamic acid 5-methyl ester having L-configuration. It is a L-glutamic acid derivative, a non-proteinogenic L-alpha-amino acid and a glutamic acid 5-methyl ester.
reaction suitability	reaction type: solution phase peptide synthesis
Synthesis	67-56-1 56-86-0 1499-55-4 L-glutamic acid (22.1 g, 0.15 mol) was suspended in methanol (450 mL) at room temperature and under nitrogen protection. Subsequently, trimethylsilyl chloride (TMSCl, 35.9 g, 0.33 mol) was slowly added dropwise over a period of 5 min, at the end of which most of the solid was observed to be dissolved. Stirring of the reaction mixture was continued for 5 min and the progress of the reaction was monitored by thin layer chromatography (TLC, Spreader: 15% ammonia in methanol solution, Color Developer: ninhydrin) to confirm that only traces of the feedstock were present and that no bis-methyl esterified product was generated. After stirring again for 5 minutes, the reaction mixture was concentrated using a rotary evaporator and subsequently dried in a vacuum oven at 40 °C to give pure L-glutamic acid-5-methyl ester as a white solid. Yield: 30.0 g (100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CD3OD, ppm) δ 2.2 (2H, m), 2.6 (2H, m), 3.7 (3H, s), 4.1 (1H, t) and 13C NMR (75 MHz, CD3OD, ppm) δ 26.6, 30.4, 52.5, 53.2, 171.4, 174.3.
References	[1] Patent: US2016/16890, 2016, A1. Location in patent: Paragraph 0163 [2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 13, p. 3793 - 3797 [3] Tetrahedron Letters, 2010, vol. 51, # 9, p. 1333 - 1335 [4] Synthesis, 1987, # 7, p. 635 - 637 [5] Organic Process Research and Development, 2004, vol. 8, # 1, p. 72 - 85

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.