White to light yellow Sunflower Lecithin Liposomal PEA powder 50%

High oral biavailability liposomal PEA 50%,70% CAS NO.544-31-0

PEA, or palmitoylethanolamine, is an endogenous fatty acid amide and a naturally occurring compound formed from palmitic acid and ethanolamine. It plays a significant role in intracellular signalling mechanisms. As a natural analgesic for chronic pain, daily intaking of 300mg or 600mg PEA significantly reduces pain in patients with mild to moderate knee osteoarthritis.

Characteristics of PEA :

PEA is lipophilic and virtually insoluble in water, resulting in low oral bioavailability: experiments demonstrate that following oral administration of 100 mg/kg to rats, only approximately 25% is absorbed. Furthermore, its volume of distribution exceeds that of plasma, with the majority of the drug rapidly leaving the bloodstream, making it difficult to maintain systemic levels. The key rate-limiting step for oral absorption is dissolution; smaller particle size facilitates faster dissolution.

Processing PEA via micronisation technology significantly enhances its bioavailability. Micronisation substantially increases the drug's specific surface area, enabling gastrointestinal fluids to wet and dissolve the particles more readily. This accelerates dissolution rates and improves absorption efficiency. This process effectively resolves absorption challenges, providing crucial support for enhancing the product's market competitiveness.

We offer PEA products in multiple specifications, including standard-grade and micronised grades, helping your products stand out in the marketplace and forge a unique competitive edge.

1. 1.Common PEA powder

1. Purity:99%
2. Particle size : 100% pass 40mesh
3. Bulk density : NLT0.30g/ml

1. 2.Micornized PEA powder.

1. Purity: 99%
2. Particle size: D(0.80~1.00) 10 µm

1. 3. Liposomal PEA

1. Specification : 50% , 70%

Bulk density: NLT 0.70-0.80 g/mL

What is liposome technology ?

Liposome technology uses microscopic, spherical vesicles called liposomes to encapsulate and deliver active ingredients like drugs or nutrients . These liposomes are made of lipid bilayers, which allow them to carry both water-soluble (hydrophilic) and fat-soluble (hydrophobic) substances, protecting them from degradation and enhancing their absorption in the body. This technology is used across pharmaceuticals, cosmetics, and food supplements to improve stability and efficacy.