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2-Hydroxypropyl-β-cyclodextrin CAS:128446-35-5

Name: 2-Hydroxypropyl-β-cyclodextrin CAS:128446-35-5
Brand: Orient
SKU: pr2512241105
Price: 4 USD
Availability: InStock

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CAS No.:

128446-35-5

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-24

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	2-Hydroxypropyl-β-cyclodextrin
Synonyms:	beta-cyclodextrin,2-hydroxypropylether;(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1340;(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1400;Hydroxypropyl-beta-cyclodextrin,97%;(2-Hydroxypropyl)-beta-cyclode;(2-Hydroxypropyl)-beta-cyclodextrin, avge. MW ca 1400;(2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480;(2-Hydroxypropyl)-β-cyclodextrin ,97%
CAS:	128446-35-5
MF:	C63H112O42
MW:	1541.54
EINECS:	420-920-1
Product Categories:	Other APIs;Carbohydrates & Derivatives;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Signal Transduction Research Tools;Synthetic Reagents;CyclodextrinsCell Culture;128446-35-5
Mol File:	128446-35-5.mol

2-Hydroxypropyl-β-cyclodextrin Chemical Properties

Melting point	278 °C (dec.)
Boiling point	400℃
density	1.05 at 20.3℃
refractive index	125 ° (C=1, H2O)
storage temp.	room temp
solubility	H₂O: 45 % (w/v)
form	solution (clear, colorless)
color	White to slightly yellow
PH	5.0-7.0 (20g/L in H2O)
biological source	synthetic (organic)
Optical Rotation	[α]26/D +139°, c = 1 in H2O
Water Solubility	Soluble in water.
Cosmetics Ingredients Functions	SKIN CONDITIONING FRAGRANCE
InChIKey	ODLHGICHYURWBS-FOSILIAISA-N
LogP	-4 at 20℃
Surface tension	63.6-65mN/m at 1g/L and 22℃
EPA Substance Registry System	.beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)

Safety Information

Safety Statements	24/25
WGK Germany	3
RTECS	GU2293332
TSCA	Yes
HS Code	29400090
Toxicity	mouse,LD,intravenous,> 5gm/kg (5000mg/kg),Journal of Pharmaceutical Sciences. Vol. 84, Pg. 1223, 1995.

MSDS Information

2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis

Structure	2-Hydroxypropyl-β-cyclodextrins (HPβCDs) are synthesized by condensation between β-cyclo-dextrin (βCD) and propylene oxide. Structure of 2-hydroxypropyl-β-cyclodextrin (HPβCD) where R = H or CH2-CHOH-CH3 is shown below. There are 21 (red) hydroxyl groups on βCD, which are potential substitution sites for the condensation reaction with propylene oxide to yield various species of HPβCD with different degrees of substitution depending upon how many sites are substituted[3].
Chemical Properties	White to slightly yellow powder
Chemical Properties	Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
Uses	2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
Uses	enteric coating, sustained release formulations, buccal and transdermal drug delivery
Uses	2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
Production Methods	Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.
General Description	(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.
Pharmaceutical Applications	Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations. Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

β-Cyclodextrin, 2-hydroxypropyl ethers

Other Name:

β-Cyclodextrin,2-hydroxypropyl ethers;94035-02-6

CAS No.:

128446-35-5

InChIKeys:

ODLHGICHYURWBS-UHFFFAOYSA-N

Molecular Weight:

1541.54

Exact Mass:

1540.662818

EC Number:

420-920-1

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

619

XLogP3:

-12.39490

Appearance:

White to slightly yellow solution (clear, colorless)

Melting Point:

278 °C (dec.)

Water Solubility:

soluble in water.

Storage Conditions:

2-8°C

See More β-Cyclodextrin, 2-hydroxypropyl ethers Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More β-Cyclodextrin, 2-hydroxypropyl ethers Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

8 Inquiries

Country	Product	Purchase Quantity	Date Posted
Turkey	Cosmetic grade cas 128446-35-5 2-Hydroxypropyl-beta-cyclodextrin / 2-Hydroxypropyl-beta-cyclodextrin 99% White powder C63H112O42	20 G	Nov 17, 2023
United States	hydroxypropyl-beta-cyclodextrin 100%, Pharmaceutical Grade	500 G	Mar 6, 2026
United Kingdom	HPBCD	500 KG	Nov 13, 2025
Vietnam	Hydroxypropyl Beta Cyclodextrin	25 KG	May 20, 2025
Vietnam	Hydroxypropyl Beta Cyclodextrin	25	May 15, 2025
United States	Hydroxypropyl Beta Cyclodextrin	1 KG	Apr 18, 2025
Indonesia	Hydroxypropyl-β-cyclodextrin	500 G	Jan 5, 2026
Israel	Hydroxypropyl-β-Cyclodextrin	300 KG	Feb 11, 2025

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