High Quality Fluralaner CAS 864731-61-3 Powder Fast Shipping Best Price

Fluralaner More Info

Introduction
Fluralaner (CAS No. 864731-61-3) is a potent, broad-spectrum isoxazoline-class ectoparasiticide designed exclusively for veterinary medicine. Developed to address the unmet need for long-acting, convenient parasite control in companion animals, it targets fleas, ticks, and certain mites that infest dogs and cats. As a systemic insecticide and acaricide, fluralaner delivers sustained efficacy through oral or topical administration, distinguishing itself from traditional ectoparasiticides by its extended protection period (up to 12 weeks per dose) and high selectivity for invertebrate nervous systems. Its rapid onset of action, broad parasite coverage, and favorable safety profile have made it a first-line choice for veterinarians and pet owners worldwide, effectively reducing the risk of parasite-borne diseases (e.g., Lyme disease, babesiosis) and improving animal welfare.
Mechanism of Action
Selective Nervous System Disruption in Parasites
Fluralaner exerts its parasiticidal effects through a highly specific mechanism targeting invertebrate neurotransmission:
Target site specificity: It binds irreversibly to γ-aminobutyric acid (GABA) receptors and glutamate-gated chloride channels (GluCls) in the nervous system of fleas, ticks, and mites. These channels are critical for regulating neuronal excitability, mediating inhibitory neurotransmission that maintains normal nervous system function.
Neurological dysfunction: By blocking GABA and GluCl channels, fluralaner disrupts inhibitory signaling, leading to uncontrolled neuronal hyperexcitation, convulsions, and eventual paralysis of the parasite. Death occurs within hours to days of exposure, depending on the parasite species.
Mammalian safety: Unlike invertebrates, mammalian GABA receptors have low affinity for fluralaner, and glutamate-gated chloride channels are primarily expressed in the central nervous system (CNS) with limited access to systemic fluralaner. This species-specific selectivity results in minimal toxicity to dogs and cats, even at therapeutic doses.
Systemic distribution: Following oral or topical administration, fluralaner is rapidly absorbed into the bloodstream and distributed throughout the body. It accumulates in the skin and hair follicles—key sites of parasite attachment—providing continuous protection as parasites feed on the host’s blood or tissue fluids.
Pharmacological Effects & Advantages
Core Pharmacological Effects
Rapid parasiticidal activity: Oral formulations kill fleas within 4–8 hours of administration and ticks within 24–48 hours, while topical formulations achieve similar efficacy within 12–24 hours for fleas and 48 hours for ticks. This rapid action prevents parasite feeding and reduces the transmission of vector-borne pathogens.
Long-acting protection: A single oral dose provides up to 12 weeks of flea control and 8–12 weeks of tick control in dogs; topical formulations offer 8–12 weeks of protection for both fleas and ticks in cats and dogs. This eliminates the need for monthly dosing, improving owner compliance.
Broad parasite spectrum: Effective against major ectoparasites of companion animals, including:
Fleas: Ctenocephalides felis, Ctenocephalides canis (adults, larvae, and eggs)
Ticks: Ixodes ricinus, Dermacentor variabilis, Amblyomma americanum, Rhipicephalus sanguineus
Mites: Sarcoptes scabiei (canine scabies), Otodectes cynotis (ear mites), Demodex canis (demodectic mange)
Persistent efficacy: Maintains therapeutic concentrations in skin and blood for weeks, ensuring protection even as new parasites infest the host. It also inhibits flea egg production, breaking the parasite life cycle.
Key Advantages
High safety profile: Well-tolerated in dogs (≥8 weeks old) and cats (≥14 weeks old) across a wide weight range. Adverse reactions are rare and mild (e.g., transient vomiting, diarrhea, lethargy), with no evidence of long-term toxicity, carcinogenicity, or reproductive harm.
Flexible administration: Available in oral chewable tablets (palatable for dogs) and topical spot-on formulations (suitable for cats and dogs), accommodating different animal preferences and owner convenience.
Resistance management: Acts on a unique target site not shared by older ectoparasiticides (e.g., pyrethroids, organophosphates), reducing the risk of cross-resistance and maintaining efficacy against parasite populations resistant to other classes.
No environmental impact: Minimal excretion in urine and feces, with low toxicity to non-target organisms (e.g., bees, fish, birds) when used as directed.
Clinical Applications
Approved Indications
Flea control: Treatment and prevention of flea infestations in dogs and cats, including the suppression of flea egg production to prevent environmental contamination.
Tick control: Prevention of tick infestations in dogs and cats, reducing the risk of tick-borne diseases (e.g., Lyme disease, ehrlichiosis, babesiosis).
Mite infestations: Treatment of sarcoptic mange (scabies) and ear mites in dogs and cats; adjunctive treatment of demodectic mange in dogs (when combined with other therapies).
Administration & Dosing Considerations
Routes of administration:
Oral: Chewable tablets for dogs (administered with or without food); available in weight-based dosages (e.g., 1–4 kg, 4–10 kg, 10–20 kg, 20–40 kg).
Topical: Spot-on solution for dogs and cats (applied to the skin between the shoulder blades); dosed based on body weight.
Dosing frequency:
Flea/tick prevention: Once every 8–12 weeks (oral) or 8 weeks (topical), depending on the formulation and parasite species.
Mite treatment: Single dose for ear mites; 1–2 doses (2–4 weeks apart) for sarcoptic mange, as directed by a veterinarian.
Special populations:
Safe for pregnant and lactating dogs and cats when used as directed.
No dose adjustment needed for animals with mild to moderate renal or hepatic impairment; caution in severely impaired animals (limited data available).
Not recommended for puppies younger than 8 weeks or kittens younger than 14 weeks.
Handling & Storage
Storage conditions: Store at 25°C (77°F) in a dry, cool place, protected from light and moisture. Keep oral formulations in their original packaging to prevent degradation; avoid exposure to extreme temperatures (below 15°C or above 30°C).
Handling precautions:
For veterinary use only—keep out of reach of children and unauthorized personnel.
When administering topical formulations, wear disposable gloves to avoid skin contact; wash hands thoroughly after handling.
Prevent pets from licking the application site for 24 hours after topical administration (use an Elizabethan collar if necessary) to avoid ingestion-related side effects.
Oral chewable tablets are palatable but should not be consumed by humans; if accidental ingestion occurs, seek medical attention.
Disposal: Dispose of unused or expired medication, empty vials/tablet blisters, and contaminated materials (e.g., gloves, applicators) in accordance with local veterinary and environmental regulations. Do not discard in household waste or wastewater.
Limitations & Research Updates
Limitations
Species restriction: Approved exclusively for dogs and cats; not recommended for other companion animals (e.g., rabbits, ferrets, birds) or livestock due to limited safety data.
Parasite resistance: Emerging reports of reduced efficacy against certain flea populations (e.g., Ctenocephalides felis) in some regions, highlighting the need for responsible use and resistance monitoring.
Adverse reactions: Rare but potential side effects include neurological signs (e.g., tremors, seizures) in animals with underlying CNS disorders; gastrointestinal upset (vomiting, diarrhea) in sensitive individuals.
Environmental exposure: While low-risk, topical formulations may contaminate water sources if rinsed off pets prematurely; avoid allowing treated animals to swim in natural water bodies for 24–48 hours post-administration.
Research Updates
New formulations: Extended-release oral formulations and combination products (e.g., fluralaner + milbemycin oxime for internal parasite control) are being developed to expand utility and improve convenience.
Expanded indications: Ongoing studies are exploring efficacy against additional mite species (e.g., Cheyletiella spp., Notoedres cati) and potential use in other companion animals (e.g., ferrets, rabbits) with appropriate dosing adjustments.
Resistance management: Research is focused on monitoring resistance patterns globally and developing strategies to mitigate resistance, such as rotating with ectoparasiticides from different classes.
Vector-borne disease prevention: Clinical trials are investigating the impact of fluralaner on reducing the transmission of emerging tick-borne pathogens (e.g., Borrelia miyamotoi, Ehrlichia ewingii) in endemic regions.
Safety in special populations: Further studies are evaluating efficacy and safety in animals with severe renal/hepatic impairment and senior pets, to expand usage guidelines.

Product Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.