Hexamethylphosphoramide RC03040
680-31-9
Industrial Grade
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceIt appears as colorless transparent flammable liquid with a medium ammonia flavor. It is soluble in water, polar and non-polar solvents.
Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992)|COLOURLESS MOBILE LIQUID.|Clear, colorless to light amber liquid with an aromatic or mild, amine-like odor.|Clear, colorless liquid with an aromatic or mild, amine-like odor. [Note: A solid below 43°F.]
Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992)|Hexamethylphosphoric triamide is a phosphoramide. It has a role as a mutagen and an insect sterilant.|Hexamethylphosphoramide is no longer used in large quantities in the United States. No information is available on the acute (short-term), chronic (long-term), reproductive, developmental, or carcinogenic effects of hexamethylphosphoramide in humans. Acute animal studies have reported effects on the kidneys and lungs from oral exposure to hexamethylphosphoramide, while chronic oral studies in animals have reported an increased incidence of lung disease. An increased incidence of nasal tumors from inhalation exposure to hexamethylphosphoramide was reported in rats. EPA has not classified hexamethylphosphoramide for carcinogenicity; however, the International Agency for Research on Cancer (IARC) has classified it as a Group 2B, possible human carcinogen.|Hexamethylphosphoramide is a clear, colorless liquid with an aromatic odor that emits toxic fumes of phosphorous oxides and nitrogen oxides when heated to decomposition. Hexamethylphosphoramide is used as a stabilizer against thermal degradation in polystyrene and is used as a solvent in research laboratories. Exposure to this substance irritates the eyes, skin and respiratory-tract. Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)|A chemosterilant agent that is anticipated to be a carcinogen.Basic Info-
Product Name:
Hexamethylphosphoramide
Other Name:Phosphoric triamide,N,N,N′,N′,N′′,N′′-hexamethyl-;Phosphoric triamide,hexamethyl-;N,N,N′,N′,N′′,N′′-Hexamethylphosphoric triamide;ENT 50,882;Hempa;Hexametapol;Hexamethylphosphoramide;Hexamethylphosphoric acid triamide;Hexamethylphosphoric triamide;Hexamethylphosphorotriamide;HPT;Phosphoric tris(dimethylamide);Phosphoryl hexamethyltriamide;Tris(dimethylamino)phosphine oxide;Hexamethylorthophosphoric triamide;HMPA;Phosphoric hexamethyltriamide;Phosphoric acid hexamethyltriamide;N,N′,N′′-Hexamethylphosphoramide;Eastman Inhibitor HPT;HMPTA;HMPT;Hexamethyltriamidophosphate;NSC 113131;NSC 7967;Light Stabilizer HPT;[Bis(dimethylamino)phosphoryl]dimethylamine;Hexamethylphosporic triamide;24992-55-0;51557-01-8
CAS No.:680-31-9
Molecular Formula:C6H18N3OP
InChIKeys:InChIKey=GNOIPBMMFNIUFM-UHFFFAOYSA-N
Molecular Weight:179.2
Exact Mass:179.20
EC Number:211-653-8
UNII:M42TU5843Z
ICSC Number:0162
NSC Number:113131|7967
UN Number:2810|3082
DSSTox ID:DTXSID6020694
NCI Thesaurus Code:C44390
Color/Form:COLORLESS, MOBILE LIQUID|Clear, colorless liquid [Note: A solid below 43 degrees F].
HScode:29299090
Categories:
Characteristics-
PSA:
26.8
XLogP3:0.77930
Appearance:Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992)
Density:1.03 g/cm3 @ Temp: 20 °C
Melting Point:5-7 °C
Boiling Point:233 °C @ Press: 760 Torr
Flash Point:222 °F
Refractive Index:n20/D 1.459(lit.)
Water Solubility:Miscible
Storage Conditions:Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.
Vapor Pressure:0.07 mm Hg ( 25 °C)
Vapor Density:6.18 (vs air)
Toxicity:LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)
Flammability characteristics:Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Odor:AROMATIC ODOR
Experimental Properties:DOES NOT HYDROLYZE IN ALKALINE MEDIA BUT HYDROLYZES SLOWLY IN ACIDS
Air and Water Reactions:Water soluble.
Reactive Group:Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Reactivity Profile:HEXAMETHYLPHOSPHORAMIDE may react with strong oxidizing agents and strong acids (NTP, 1992). Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Flammable Limits:Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H340 May cause genetic defects
H350 May cause cancer
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Ventilation along the floor.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
