Name | Decapeptide-12 |
CAS number | 137665-91-9 |
Description | Decapeptide-12 is a synthetic peptide composed of ten amino acids, with its sequence often proprietary and optimized for specific cosmetic or biochemical functions. |
Structural formula | |
Molecular Formula | C65H90N18O17 |
Molecular Weight | 1395.42 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Decapeptide-12 is a synthetic peptide composed of ten amino acids, with its sequence often proprietary and optimized for specific cosmetic or biochemical functions. Its molecular design typically incorporates modifications, such as acetylation, to enhance stability, skin penetration, and biological activity. As a peptide, its three-dimensional structure and specific side-chain interactions are crucial for its mode of action, which is usually designed to mimic or interfere with natural biological processes involved in skin aging, pigmentation, or inflammation.
The proposed mechanism of action for Decapeptide-12 varies based on its specific engineered sequence. For anti-aging applications, a common mechanism is the downregulation of collagen-degrading enzymes like matrix metalloproteinases, thereby protecting the skin's extracellular matrix. In formulations targeting hyperpigmentation, it may act by inhibiting the melanogenesis pathway, often through interference with the binding of α-MSH to the melanocortin-1 receptor or by reducing tyrosinase activity. This targeted approach aims to correct specific aesthetic concerns at a cellular signaling level.
The primary application of this peptide is as a high-value active ingredient in the cosmetic and personal care industry. It is formulated into targeted skincare products such as anti-wrinkle serums, brightening creams, firming lotions, and products designed to improve skin tone and elasticity. It represents a shift towards using biomimetic, signal-interfering molecules in cosmetics to achieve functional benefits beyond simple hydration or occlusion, aligning with the "cosmeceutical" trend.
From a development and formulation standpoint, Decapeptide-12 is a challenging yet powerful ingredient. Supplied as a white lyophilized powder or a standardized solution, it requires careful integration into cosmetic bases. Formulators must ensure compatibility with other ingredients, maintain an appropriate pH for peptide stability, and often use delivery systems like liposomes or nanospheres to enhance its penetration through the stratum corneum to reach its target cells in the viable epidermis. Its efficacy is concentration-dependent, typically used in low ppm ranges.
The safety profile of such cosmetic peptides is generally outstanding. They are designed to be non-toxic, non-irritating, and non-sensitizing at their intended use concentrations. Due to their peptide nature and topical application with minimal systemic absorption, they present a very low risk of adverse reactions. Comprehensive safety assessments, including in vitro toxicology and human repeat insult patch tests, are standard. While its cosmetic efficacy is supported by in vitro, ex vivo, and clinical usage studies, it is important to note that, as a cosmetic ingredient, it is not held to the same efficacy demonstration standards as a pharmaceutical drug.
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