*Product Photos
Product Introduction
| Item | Details |
| CAS No. | 72957-37-0 |
| Names | Tripeptide-1 (GHK, Glycyl-Histidyl-Lysine) |
| Purity | >99 |
1. Product Overview
Tripeptide-1, also known as GHK or Glycyl-Histidyl-Lysine, has a CAS number of 72957-37-0, a molecular formula of C14H24N6O4, and a molecular weight of 340.38 g/mol. Its chemical structure is a linear tripeptide chain composed of glycine, histidine, and lysine (Gly-His-Lys). The product appears as a white to off-white free-flowing powder with no visible impurities. In terms of purity, the Cosmetic Grade reaches ≥99.8% (tested by HPLC), while the Pharmaceutical Grade achieves ≥99.9% (tested by HPLC). It is easily soluble in water with a solubility of ≥100 mg/mL and insoluble in chloroform and ether. The pH value of a 1% aqueous solution at 25℃ ranges from 5.0 to 7.0. The moisture content, determined by the Karl Fischer method, is ≤0.5%, and the ash content is ≤0.1%. For heavy metal control, the total heavy metal content is ≤10 ppm, with lead (Pb) ≤2 ppm, arsenic (As) ≤1 ppm, and mercury (Hg) ≤0.1 ppm. Regarding microbial limits, the total aerobic microorganisms are ≤100 CFU/g, yeast and mold are ≤10 CFU/g, and Escherichia coli and Salmonella are negative. The product is stable under cool, dry, and sealed conditions; the shelf life is 2 years in the original packaging when stored at 2-8℃, and 6 months when stored at room temperature (≤25℃). It is available in two grades: Cosmetic Grade (ISO 9001 certified) and Pharmaceutical Grade (GMP compliant). The production process adopts solid-phase peptide synthesis, followed by purification via reverse-phase high-performance liquid chromatography (RP-HPLC). The detection methods include HPLC (High-Performance Liquid Chromatography), MS (Mass Spectrometry), and amino acid analysis.
Tripeptide-1 is a naturally occurring bioactive tripeptide widely present in human plasma, saliva, and skin tissue, playing a crucial role in regulating skin cell metabolism and tissue repair. As a high-purity peptide raw material, our product is manufactured in a GMP-compliant and ISO 9001-certified workshop. We adopt advanced solid-phase synthesis technology and multi-step purification processes (including RP-HPLC and ultrafiltration) to ensure high bioactivity and low impurity content. The product is non-irritating, non-toxic, and complies with international standards such as USP, EP, and GB, meeting the strict requirements of the cosmetic, medical aesthetic, and pharmaceutical industries for raw material quality. With uniform particle size and good flowability, it is easy to dissolve and blend in various formulations, ensuring stable performance in end products.
2. Functional Effects
Tripeptide-1 exhibits multiple bioactive functions that make it a core raw material in skin care and medical fields. Firstly, it promotes collagen and elastin synthesis: it specifically binds to copper ions (Cu²⁺) to form a GHK-Cu complex, which activates skin fibroblasts, upregulates the expression of collagen type I, III, and elastin genes, and increases the synthesis of extracellular matrix proteins, thereby enhancing skin firmness and reducing sagging. Secondly, it has anti-aging and wrinkle reduction effects: it replenishes the loss of endogenous peptides in aging skin, improves skin texture roughness caused by collagen degradation, and fades fine lines, crow's feet, and expression lines by enhancing skin structural support. Thirdly, it supports skin barrier repair and soothing: it accelerates the proliferation and differentiation of keratinocytes, promotes the synthesis of skin barrier lipids (ceramides, cholesterol), repairs damaged stratum corneum, and relieves skin sensitivity, redness, and dryness caused by external stimuli (such as UV radiation, chemical ingredients, and mechanical damage). Fourthly, it provides antioxidant and free radical scavenging capabilities: it inhibits the activity of matrix metalloproteinases (MMPs) that degrade collagen, scavenges reactive oxygen species (ROS) generated by oxidative stress, reduces lipid peroxidation, and delays skin aging caused by environmental factors. Additionally, it offers moisturizing and nourishing benefits: it enhances the skin's hydration retention capacity by regulating the expression of aquaporins, maintains the moisture balance of the stratum corneum, and leaves the skin soft, smooth, and radiant.
3. Applications
Tripeptide-1 has a wide range of applications across cosmetic, medical aesthetic, pharmaceutical, and personal care industries. In cosmetic formulations, it is widely used in serums, creams, eye care products (such as eye creams and eye masks), facial masks, lotions, and specialized anti-aging skincare lines, effectively enhancing the anti-aging, firming, and repairing effects of the products. In the medical aesthetic field, it is an important raw material for medical dressings (such as repair masks and hydrogels), post-procedure repair products (used after laser, photon, and other medical aesthetic treatments), and professional skincare formulations for clinics, helping to speed up skin recovery and reduce irritation. For pharmaceutical products, the Pharmaceutical Grade Tripeptide-1 is used in topical preparations for skin repair and anti-inflammatory treatments, such as ointments and lotions for treating damaged skin and mild inflammatory conditions. In personal care, it is also added to high-end hair care products (including anti-hair loss shampoos, hair masks, and repair serums) to nourish the scalp, strengthen hair follicles, and improve hair quality, as well as body care formulations (such as body lotions and repair creams) to enhance skin elasticity and moisture retention.
4. Packaging
We offer flexible and customizable packaging options to meet the diverse needs of different orders and customers.
5. Storage Conditions
To ensure the stability, bioactivity, and shelf life of Tripeptide-1, proper storage conditions are essential. The product should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, high temperatures (avoid storage above 30℃), and sources of moisture (such as humid basements or areas near water sources). After opening the packaging, it must be sealed tightly immediately after use to prevent moisture absorption, oxidation, or contamination by external impurities. It should be stored separately from strong acids, alkalis, oxidizing agents, and other incompatible substances to avoid chemical reactions that may affect product quality. For long-term storage (more than 3 months), the recommended storage temperature is 2-8℃ (such as in a refrigerator), which can effectively maintain the product's bioactivity and stability. For short-term storage (within 3 months), it can be stored at room temperature, but the environment must be dry and well-ventilated with a temperature not exceeding 25℃. During transportation, it should be protected from sunlight, rain, and heavy pressure to prevent packaging damage and product deterioration.
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