Factory Supply Octenidine Dihydrochloride USP Standard Raw Powder CAS 70775-75-6 with Competitive Price

Octenidine dihydrochloride  More Info

Octenidine dihydrochloride is a cationic bispyridine antiseptic agent widely used in clinical practice for the prevention and treatment of local infections . Chemically designated as N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine dihydrochloride, it has a molecular formula of C36H64Cl2N4 and a molecular weight of approximately 623.8 g/mol . Developed in the 1980s, this compound was specifically designed as an alternative to chlorhexidine, offering a broader antimicrobial spectrum with comparable or superior tissue tolerance .

The antimicrobial mechanism of octenidine is fundamentally based on its physicochemical interaction with microbial cell membranes. As a cationic surfactant, its positively charged molecules are electrostatically attracted to the negatively charged components of bacterial and fungal cell envelopes . This interaction disrupts membrane integrity, leading to leakage of intracellular components and eventual cell death . Unlike many antibiotics that target specific metabolic pathways, this membrane-active mechanism makes the development of resistance highly unlikely, as it would require complete restructuring of the microbial cell envelope . Recent research has further elucidated that octenidine can impair ergosterol biosynthesis in fungi and induce reactive oxygen species generation, compromising cell membrane integrity in pathogens such as Candida albicans .

Octenidine demonstrates a remarkably broad spectrum of antimicrobial activity with rapid onset. It is effective against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), as well as fungi and some enveloped viruses . For most susceptible species, minimum inhibitory concentrations range from approximately 1 to several micrograms per milliliter . One of its most valuable clinical properties is its potent antibiofilm activity; it not only inhibits the formation of biofilms but also disrupts mature biofilms, which are notoriously difficult to eradicate with conventional antimicrobials . The required contact time for microbicidal action is rapid, often achieving significant reduction within one minute .

Clinically, octenidine is employed in a wide variety of applications due to its favorable efficacy and safety profile. It is considered a first-choice antiseptic for critically colonized wounds, infection-prone wounds, burns, and wounds colonized by multidrug-resistant pathogens, as well as for the prevention of surgical site infections . Additional applications include umbilical stump care, treatment of oral infections, skin and mucosal candidiasis, and bacterial vaginosis . Formulations typically contain octenidine in aqueous solution, often combined with phenoxyethanol as a solvent and preservative, though research into lipid-based formulations aims to reduce the irritant potential of phenoxyethanol for sensitive applications .

The safety profile of octenidine is well-established, with a high biocompatibility index indicating a wide margin between antimicrobial efficacy and cytotoxic effects on human cells . Its Clinical Efficiency of MIC (CEMIC) index is classified as excellent for most pathogens, meaning that clinically used concentrations are substantially higher than the minimum inhibitory concentrations required . The risk of bacterial adaptation or resistance development is considered very low for most species, with the Karpinski Adaptation Index remaining below 0.2 for the vast majority of organisms . However, as with any potent antiseptic, it should be used according to established guidelines to maintain its efficacy and safety profile in clinical practice .

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.