High Purity Ecdysone Cell Renewal Activating Radiant Skincare Raw Material

Description：

Ecdysterone (β-ecdysone), a hormone that regulates insect growth and metabolism, was initially studied by entomologists. In 1954, Butenandt et al. isolated 250 mg of the original insect metamorphic active substance, ecdysone, from 500 kg of silkworm pupae. Subsequently, numerous similar substances were isolated from various plant species. It was discovered that ecdysteroids (ecdysone-like substances) are not only more abundant but also more widely distributed in the plant kingdom compared to the animal kingdom, and they are rich in resources. For example, domestic plants such as Achyranthes bidentata, Cyathula officinalis, mulberry leaves, Common Selfheal (Prunella vulgaris) with white-haired varieties, Alisma orientale, Podocarpus macrophyllus, Taxus spp., Onychium japonicum, and Osmunda japonica (a type of fern) all contain ecdysteroid analogs. It was through research on the mechanism of action of ecdysone that people realized that steroid substances exert their effects by altering genetic activity and influencing genetic information transcription. Over the subsequent years, the structure of ecdysone was determined, and the pharmacological effects of ecdysteroids, particularly ecdysterone, began to attract research interest. Studies in the past two decades have revealed that ecdysterone also exhibits strong pharmacological activity in higher animals.

Actions:

1. Promotion of nucleic acid and protein synthesis: The earliest research on ecdysterone focused on its anabolic effects.
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3. Influence on glucose metabolism: The effects of ecdysterone on mammals, including its impact on glucose metabolism, are mediated through the cAMP-protein kinase system.
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5. Promotion of lipid metabolism: The regulatory effects of ecdysterone on lipid metabolism are related to its action on the cAMP-protein kinase system.
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7. Immunomodulatory effects: The inhibitory effect of ecdysterone on histamine release from rat peritoneal mast cells may be related to its inhibitory effect on the mobilization of intracellular stored calcium.
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9. Effects on the central nervous system: As an insect growth and metabolism regulatory hormone, ecdysterone also exhibits a wide range of pharmacological effects in higher animals, with minimal toxic side effects, and is widely distributed in the plant kingdom. In-depth research on the pharmacological effects of ecdysterone can not only provide a basis for the mechanism of action of many traditional Chinese medicines.