Diclofenac Sodium Double Release Enteric Coated Capsules

Both in vivo and in vitro tests have shown that diclofenac sodium can inhibit the activity of cyclooxygenase, thereby inhibiting the synthesis of prostaglandins and affecting their release, so it has antipyretic and analgesic effects. Diclofenac sodium can inhibit platelet aggregation and prolong prothrombin time. There are two metabolites of diclofenac sodium that are also biologically active, but their activity is much lower than that of diclofenac sodium. One of them is 4-hydroxydiclofenac sodium, whose anti-inflammatory activity is 3% of diclofenac sodium, equivalent to 6 times that of aspirin.

The main ingredient of this product is diclofenac sodium.

Acute joint inflammation and gout attacks, chronic joint inflammation, rheumatoid arthritis, ankylosing spondylitis and other inflammatory rheumatic diseases of the spine, pain associated with degenerative diseases of the joints and spine, soft tissue rheumatism, swelling, pain or inflammation after trauma or surgery, treatment of dysmenorrhea and postoperative pain and inflammation caused by plastic surgery, dental surgery or other minor surgical procedures.

The normal adult dosage is once a day, 1 tablet at a time. If necessary, it can be increased to 2 times a day, 1 tablet at a time. Children and the elderly should take this medicine under the strict guidance of a doctor.

Adverse reactions are often dose-dependent. Common adverse reactions are gastrointestinal discomfort, such as nausea, vomiting, diarrhea or loss of appetite, and sometimes headache, dizziness, fatigue, rash and gastrointestinal bleeding. Cases of liver or kidney damage have been reported rarely, including increased serum liver enzyme levels, jaundice, proteinuria and hematuria.

1. Patients with known allergies to this product. 2. Patients who have asthma, urticaria or allergic reactions after taking aspirin or other non-steroidal anti-inflammatory drugs. 3. Contraindicated for the treatment of perioperative pain in coronary artery bypass grafting (CABG). 4. Patients with a history of gastrointestinal bleeding or perforation after the use of non-steroidal anti-inflammatory drugs. 5. Patients with active peptic ulcers/bleeding; or patients with recurrent ulcers/bleeding in the past. 6. Patients with severe heart failure. 7. Patients with known allergies to acetylsalicylic acid and ibuprofen. 8. Patients with a history of gastrointestinal inflammatory diseases (ulcerative colitis, Crohn's disease), melena or unexplained blood diseases.

Precautions for children: The safety and effectiveness of this product in children have not been established. Precautions for pregnancy and lactation: 1. There is no sufficient research data on the use of this product in pregnant women, so it can only be used when the benefits of using this product to pregnant women outweigh the potential harm to the fetus. This drug may have adverse effects on the fetus, may affect the cardiovascular system of the fetus, and lead to premature closure of the ductus arteriosus, so it should be avoided during pregnancy. 2. Similar to other non-steroidal anti-inflammatory drugs, diclofenac can inhibit uterine contractions, may cause late delivery, and increase bleeding tendency, so Diclofenac is prohibited in the last three months of pregnancy. Because this drug may have potential harm to infants, after weighing the importance of this drug to breastfeeding women, it should be decided to stop breastfeeding or stop taking this drug. Precautions for the elderly: The safety, effectiveness and occurrence of adverse reactions of this product in the elderly are not significantly different from those in young people, but the elderly generally have poor tolerance to adverse reactions, and the elderly should take this drug under the strict guidance of a doctor.

The use of other antipyretic analgesics such as glucocorticoids and acetylsalicylic acid while using Difen can increase the risk of gastrointestinal bleeding. The use of digoxin, phenytoin sodium, lithium or methotrexate while using Difen can lead to increased levels of these drugs in the serum. The simultaneous use of Difen and potassium-sparing diuretics can lead to increased blood potassium levels. The simultaneous use of Difen and cyclosporine can aggravate the damage of cyclosporine to the kidneys.

Seal tightly and store in a dry place below 25℃.

75 mg/capsule

60 months