EPO|Premium in stock

Core Mechanism of Action (For Research Only)

1. Erythropoiesis Regulation (Primary Pathway)
   • Binds to EPO receptors (EPOR) on bone marrow erythroid progenitors (BFU-E, CFU-E)
   • Activates JAK2/STAT5, PI3K/Akt, MAPK/ERK signaling cascades.
   • Inhibits apoptosis of erythroid precursors; drives proliferation, differentiation, and hemoglobin synthesis.
   • Accelerates release of reticulocytes and mature RBCs into circulation.
   • Maintains red blood cell mass and tissue oxygenation; responds to hypoxia via negative feedback.
2. Extra-Hematopoietic Effects (Research Focus)
   • Neuroprotection: Supports neuronal survival and reduces ischemic injury in CNS models.
   • Anti-inflammatory: Modulates cytokine profiles and oxidative stress in tissue injury models.
   • Angiogenesis: Promotes endothelial cell function in hypoxic tissues.

Premium Grade Specifications & Quality

• Purity: ≥99.0% (HPLC)
• Potency: Standardized at 10,000 IU/mg (biological activity)
• Formats: 5,000 IU/vial; 10,000 IU/vial; 20,000 IU/vial (lyophilized)
• QC Standards:
  • Single impurity ≤1.0%; total impurities ≤2.0%
  • Endotoxin <0.5 EU/mg; sterile filtered
  • Heavy metals ≤10 ppm; Arsenic ≤2 ppm
  • Moisture ≤1.0%; full COA provided
• Stock: In stock for immediate shipment