Pyrimethamine RC12733
58-14-0
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferencePyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).IC50 Value: 15.4 nM (Plasmodium falciparum) [1]Target: DHFR; antifolatein vitro: Three susceptibility levels (susceptible, intermediate, and resistant) were observed in the response of culture-adapted clones and strains to pyrimethamine (50% inhibitory concentration [IC50]) < 100, 100-2,000, and > 2,000
Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.|Solid
Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.|Pyrimethamine is an aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis. It has a role as an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an antiprotozoal drug. It is an aminopyrimidine and a member of monochlorobenzenes.|One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.|Pyrimethamine is a Dihydrofolate Reductase Inhibitor Antimalarial. The mechanism of action of pyrimethamine is as a Dihydrofolate Reductase Inhibitor.|Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)|One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.Basic Info-
Product Name:
Pyrimethamine
Other Name:2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;Pyrimidine,2,4-diamino-5-(p-chlorophenyl)-6-ethyl-;5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;4753 R.P.;BW 50-63;Chloridin;Chloridine;Darapram;Daraprim;2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine;Malocide;Pyrimethamine;Daraprime;5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine;2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine;Darachlor;Malocid;Pirimetamin;Tindurin;Khloridin;Malacid;Pyrimethamin;Pirimecidan;Diaminopyritamin;Erbaprelina;NSC 3061;WR 2978;RP 4753;Tinduring
CAS No.:58-14-0
Molecular Formula:C12H13ClN4
InChIKeys:InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N
Molecular Weight:248.71
Exact Mass:248.71
EC Number:200-364-2
UNII:Z3614QOX8W
NSC Number:757306|3061
UN Number:2811
DSSTox ID:DTXSID9021217
NCI Thesaurus Code:C788
Color/Form:Crystals|White scored tablets contains 25 mg pyrimethamine /Daraprim/
ATC Code:P01BD01|P - Antiparasitic products, insecticides and repellents
HScode:2933599090
Categories:
Characteristics-
PSA:
77.8
XLogP3:2.7
Appearance:Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.
Density:1.4±0.1 g/cm3
Melting Point:233.5 °C
Boiling Point:491.5°C at 760 mmHg
Flash Point:176.6±30.7 °C
Refractive Index:1.667
Water Solubility:H2O: <0.01 g/100 mL at 21 ºC
Storage Conditions:0-6°C
Vapor Pressure:1.32X10-8 mm Hg at 25 deg C (est)
Toxicity:LD50 oral in rat: 440mg/kg
PKA:7.34(at 20 °C)
Henrys Law Constant:Henry's Law constant = 1.08X10-10 atm-cu m/mol at 25 °C (est)
Dissociation Constants:7.34 (at 20 °C)|pKa = 7.34 at 20 °C (conjugate acid)
Collision Cross Section:155.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molecule-sec at 25 °C (est)
Air and Water Reactions:Insoluble in water.
Reactive Group:Amines, Phosphines, and Pyridines
Reactivity Profile:PYRIMETHAMINE is sensitive to exposure to light (NTP, 1992). Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store at 15 deg to 25 deg C (59 deg to 77 deg F) in a dry place and protect from light.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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