What is IGF-1 LR3?
IGF-1 and its analogs such as Long R3 IGF-1, des(1-3)IGF-1 and R3-IGF-I, have mitogenic effects, which speed up cell replication in different tissues.
IGF-1 LR3 was developed to improve the stability and efficiency of IGF-1 for stimulating cell growth in in vitro experiments. Adding IGF-1 LR3 to cell culture speeds up cell division, which shortens the time to conduct laboratory studies.
IGF-1 LR3 achieves this by activating the IGF-1 receptors found in most human and animal cells. Activating these anabolic receptors also stimulates protein synthesis and tissue growth.
Difference between IGF-1 and IGF-1 LR3
Most of the IGF-1 naturally found in your body binds to serum proteins called IGF-1 binding proteins. This prolongs its half-life by up to 15 hours but reduces the affinity to the IGF-1 receptors.
In comparison, the IGF-1 LR3 analog appears to have a higher affinity to the anabolic IGF-1 receptors and binds less to serum proteins.
As a result, IGF-1 LR3 has enhanced potency, and animal studies report that continuous infusion with LR3 IGF-1 had up to 2-fold higher anabolic effects than IGF-1. Tested animals experienced higher weight gain and an increase in the weight of some of their organs.
The half-life of IGF-1 LR3
Currently, there is no clinical evidence reporting its half-life in the human body, but the common beliefs you may find on the Internet that it is longer than that of IGF-1 (up to 20-30 hours) appear to be unsubstantiated.
In fact, LR3 IGF-1 is most likely eliminated quite fast in the human body due to the fact that it binds less to serum proteins such as IGF-1 binding protein.
What is more, studies in mice report that IGF-1 LR3 is eliminated entirely within 4 hours of intramuscular , meaning its half-life in mice is less than 1 hour. The metabolites of IGF-1 LR3 had a slightly longer half-life and were detectable for up to 16 hours.
In terms of effects, animal research reveals that administering IGF-1 LR3 helps protect against muscle mass loss and catabolism during reduced periods of energy intake. The peptide was infused for 8 hours, significantly suppressing the natural IGF-1 production.
Yet, there is no clinical research reporting on its effects on humans, so there is no guarantee it will work the same way. IGF-1 LR3 is also not meant for human use and can be legally obtained only for research purposes.
LR3 IGF-1 is available as a sterile filtered white lyophilized (freeze-dried) powder that must be reconstituted with distilled water and used for research purposes only. The vial sizes range from 0.2 to 1 mg.
For research purposes, the vial must be reconstituted with 2-10 ml of sterile water until achieving a concentration of 0.1 mg per milliliter. Afterward, the solution should be stored in a refrigerator at 4°C for 2-7 days.
These patients take 0.04–0.12 mg/kg of IGF-1 twice daily subcutaneously, which is equal to at least 5.6 mg of IGF-1 per day for a 70 kg person.
Despite the fact that IGF-1 LR3 is an analog with 2-3 times higher potency and purportedly longer half-life, it is unlikely that taking it in doses more than ten times lower than IGF-1 may provide any noticeable effects.
1. How to make an order?
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2. What's the lead time and shipping ways?
We will delivery to the package by USPS, FEDEX, DHL paket and UPS express to you after receive your payment, it would take around 5-15 days to your address.
3. How do i keep the peptides when i receive it ?
Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.
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