API Tauroursodeoxycholic acid

Tauroursodeoxycholic acid More Info

Product Overview

Tauroursodeoxycholic acid, commonly known as TUDCA, is a water-soluble bile acid that is naturally produced by the body and found in liver bile. TUDCA is the taurine conjugate form of ursodeoxycholic acid (UDCA), formed when the amino group of taurine conjugates with the carboxyl group of UDCA.

TUDCA is the active ingredient of bear bile, which has excellent curative effect in the treatment of gallstones and liver disease. Humans are found to have trace amounts of TUDCA, whereas bears contain large amounts of TUDCA in their bile. UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears.

TUDCA has been used in traditional Chinese medicine for over 3,000 years. It has been used in ancient Asian pharmacopoeias for its supposed beneficial effects.

Chemical Information

Chemical Name: 2-[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid

CAS Registry Number: 14605-22-2

Molecular Formula: C₂₆H₄₅NO₆S

Molecular Weight: 499.71 g/mol

Synonyms: TUDCA, 3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Ursodoxicoltaurine, UR-906, 3α,7β dihydroxycholanoyl-N-taurine

Physical Properties

Appearance: White solid or crystalline powder

Assay/Purity: ≥99.00%

Density: 1.216 g/cm³

Boiling Point: 496.4°C at 760mmHg

Melting Point: 173-175°C

Flash Point: 214.2°C

Refractive Index: 46° (C=1, EtOH)

Safety Information: RTECS: KI7372500; Safety Statements: S22, S24/25

Storage & Packaging

Storage: TUDCA is shipped in secure, sealed containers, protected from light, moisture, and extreme temperatures.

Packing: White, sealed plastic bottle labeled "Tauroursodeoxycholic Acid (TUDCA)," with safety warnings, product details, and tamper-evident cap.

Shipping: Express and temperature-controlled options are available to ensure product integrity during transit.

Therapeutic Applications

TUDCA is mainly used for the treatment of cholesterol gallstones in the gallbladder, primary sclerosing cholangitis, primary biliary cirrhosis, chronic hepatitis C virus and so on.

UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis.

Biological Functions & Benefits

TUDCA is a naturally occurring bile acid with potent liver and nerve cell protection. It supports liver function, promotes healthy bile flow, and aids cellular health.

Liver Health: TUDCA demonstrates liver support capabilities. It helps increase bile flow.

Neuroprotection: TUDCA demonstrates neuroprotective benefits.

Cellular Support: TUDCA functions primarily as a cytoprotective agent by inhibiting apoptosis, reducing endoplasmic reticulum stress, and stabilizing mitochondrial membranes.

Metabolism: TUDCA supports the digestion and utilization of fats and oils.

Cellular Detoxification: TUDCA aids in cellular detoxification processes.

Product Forms & Specifications

Capsule Form:

Potency: 250 mg per capsule

Higher Dosage: Available up to 1200 mg per serving

Packaging: 30 vegetable capsules or 60 capsules per container

Suggested Use: Take 2 capsules daily

With or Without Food: Flexible usage

Powder Form:

Purity: ≥99%

Package: Available in various batch sizes

Standard: Every batch undergoes rigorous testing to ensure consistent efficacy and safety standards

Quality Control

As an accredited TUDCA manufacturer, strict quality protocols are enforced with every batch undergoing rigorous testing to ensure consistent efficacy and safety standards.

Manufacturing: The product is manufactured in a state-of-the-art cGMP facility.

Certification: Product-specific testing may be verified by third-party organizations.