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4-Chloronitrobenzene100-00-5

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Unit Price:

$33-34/MT FOB

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CAS No.:

100-00-5

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Product Detail

4-Chloronitrobenzene Basic information

Product Name:	4-Chloronitrobenzene
Synonyms:	1-CHLORO-4-NITROBENZENE;4-Nitro-1-chlorobenzene;4-Chloro-1-nitrobenzene;4-CHLORONITROBENZENE;4-NITROCHLOROBENZENE;P-NITROCHLOROBENZENE;PNCB;PARA NITROCHLOROBENZENE
CAS:	100-00-5
MF:	C6H4ClNO2
MW:	157.55
EINECS:	202-809-6
Product Categories:	Dyestuff Intermediates;alkyl chloride \| nitro-compound;Intermediates of Dyes and Pigments;Organics;Alpha Sort;Analytical Standards;Nitro Compounds;AromaticsVolatiles/ Semivolatiles;C;CAlphabetic;CHChemical Class;Chemical Class;ChloroAnalytical Standards;Halogenated;Nitrogen Compounds;Organic Building Blocks
Mol File:	100-00-5.mol

4-Chloronitrobenzene Chemical Properties

Melting point	80-83 °C(lit.)
Boiling point	242 °C(lit.)
density	1.298 g/mL at 25 °C(lit.)
vapor density	5.4 (vs air)
vapor pressure	0.09 mm Hg ( 25 °C)
refractive index	1.5376 (estimate)
Fp	>230 °F
solubility	Soluble in acetone and alcohol (Weast, 1986)
form	Crystals or Flakes
color	Yellow
Water Solubility	Insoluble
Merck	14,2151
BRN	508691
Henry's Law Constant	4.90 x 10^-6 atmm³/mol at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
Exposure limits	ACGIH TLV-TWA:0.1 ppm (0.64 mg/m3) OSHA PEL-TWA:1 mg/m³ NIOSH IDLH:100
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, hydroxides. Reacts violently with sodium methoxide in methanol.
InChI	1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H
InChIKey	CZGCEKJOLUNIFY-UHFFFAOYSA-N
SMILES	[O-][N+](=O)c1ccc(Cl)cc1
CAS DataBase Reference	100-00-5(CAS DataBase Reference)
IARC	2B (Vol. 65, 123) 2020
NIST Chemistry Reference	Benzene, 1-chloro-4-nitro-(100-00-5)
EPA Substance Registry System	p-Chloronitrobenzene (100-00-5)

Safety Information

Hazard Codes	T,N
Risk Statements	23/24/25-40-48/20/21/22-51/53-68
Safety Statements	28-36/37-45-61-28A
RIDADR	UN 1578 6.1/PG 2
WGK Germany	2
RTECS	CZ1050000
Autoignition Temperature	500 °F
Hazard Note	Very Toxic
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	II
HS Code	29049085
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Chronic 2 Carc. 2 Muta. 2 STOT RE 2
Hazardous Substances Data	100-00-5(Hazardous Substances Data)
Toxicity	LD₅₀ (skin) for rats 16 gm/kg (quoted, RTECS, 1985).
IDLH	100 mg/m3

MSDS Information

Provider	Language
PNCB	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Chloronitrobenzene Usage And Synthesis

Chemical Properties	4-Chloronitrobenzene is a light yellow monoclinic prisms crystallizes, which are insoluble in water and very soluble in toluene, ether, acetone, or hot ethanol. It is incompatible with strong oxidizers and alkalis. It is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals.
Physical properties	p-Nitrochlorobenzene is a yellow crystalline solid with a sweet odor.
Uses	4-Nitrochlorobenzene is an important intermediate in the manufacture of azo dyes and sulfide dyes, the drugs finasteride and paracetamol, the pesticide herbicide, etc. It is also the raw material of rubber antioxidant 4010.
Uses	p-Nitrochlorobenzene is largely used to produce p-nitrophenol with smaller production of p-nitroaniline.
Uses	Manufacture of dyes, rubber, and agricultural chemicals
Definition	ChEBI: 4-Chloronitrobenzene is a C-nitro compound.
Production Methods	p-Nitrochlorobenzene is made by the nitration of chlorobenzene.
Synthesis Reference(s)	The Journal of Organic Chemistry, 52, p. 2407, 1987 DOI: 10.1021/jo00388a014 Tetrahedron Letters, 19, p. 4519, 1978
General Description	Light yellow crystalline solid. Density 1.520 g / cm3. Melting point 83°C. Sweet odor. Very toxic by inhalation, ingestion, and skin absorption. p-Chloronitrobenzene is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals. It is incompatible with strong oxidisers and alkalis.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	4-Chloronitrobenzene reacts with oxidizing agents. Reacts violently and finally explosively when added to a solution of sodium methoxide in methanol. . Unstable when heated.
Hazard	A questionable carcinogen. Very toxic by inhalation and ingestion. Absorbed via skin. Combustible. Methemoglobinemia.
Health Hazard	Repeated exposure to high levels of p-chloronitrobenzene causes adverse health effects. The symptoms of toxicity include, but are not limited to, anoxia, unpleasant taste, anemia, methemoglobinemia, hematuria (blood in the urine), spleen, kidney, bone marrow changes, and reproductive effects. The target organs of p-chloronitrobenzene poisoning have been identifi ed as the blood, liver, kidneys, cardiovascular system, spleen, bone marrow, and reproductive system.
Fire Hazard	4-Chloronitrobenzene is combustible.
Safety Profile	Confirmed carcinogen with experimental carcinogenic data. A poison by ingestion. Experimental reproductive effects. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. May explode on heating. Potentially violent reaction with sodium methoxide. When heated to decomDosition it emits very toxic fumes of NOx and Cl-. See also other chloronitrobenzene entries and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
Potential Exposure	p-Nitrochlorobenzene (PNCB) is used as an intermediate in pesticide (parathion) manufacture, drug (phenacetin and acetaminophen) manufacture; and in dye making; rubber and antioxidant manufacture.
Carcinogenicity	No increase in tumor incidence was seen in rats fed up to 1000 ppm in the diet for 2 years; in mice, results were equivocal, with high-dose animals showing an increase in vascular tumors and low-dose males showing an increase in liver tumors.6 The IARC has determined that there is inadequate evidence in experimental animals and humans for the carcinogenicity of chlorobenzenes.7
Environmental fate	Biological. Under aerobic conditions, the yeast Rhodosporidium sp. metabolized pchloronitrobenzene to 4-chloroacetanilide and 4-chloro-2-hydroxyacetanilide as final major metabolites. Intermediate compounds identified include 4-chloronitrosobenzene, 4-chlorophenylhydroxylamine, and 4-chloroaniline (Corbett and Corbett, 1981). Under continuous flow conditions involving feeding, aeration, settling, and reflux, a mixture of p-chloronitrobenzene and 2,4-dinitrochlorobenzene was reduced 61–70% after 8–13 d by Arthrobacter simplex, a microorganism isolated from industrial waste. A similar experiment was conducted using two aeration columns. One column contained A. simplex, the other a mixture of A. simplex and microorganisms isolated from soil (Streptomyces coelicolor, Fusarium sp., probably aquaeductum and Trichoderma viride). After 10 d, 89.5–91% of the nitro compounds was reduced. p-Chloronitrobenzene was reduced to 4-chloroaniline and six unidentified compounds (Bielaszczyk et al., 1967). Photolytic. An aqueous solution containing p-chloronitrobenzene and a titanium dioxide (catalyst) suspension was irradiated with UV light (λ >290 nm). 2-Chloro-5-nitrophenol was the only compound identified as a minor degradation product. Continued irradiation caused additional degradation yielding carbon dioxide, water, hydrochloric and nitric acids (Hustert et al., 1987). Irradiation of p-chloronitrobenzene in air and nitrogen produced 4-chloro-2-nitrophenol and 4- chlorophenol, respectively (Kanno and Nojima, 1979). Chemical. Although no products were identified, p-chloronitrobenzene (1.5 x 10^-5 M) was reduced by iron metal (33.3 g/L acid washed 18–20 mesh) in a carbonate buffer (1.5 x 10^-2 M) at pH 5.9 and 15 °C. Based on the pseudo-first-order disappearance rate of 0.0336/min, the half-life was 20.6 min (Agrawal and Tratnyek, 1996).
Shipping	UN1578 Chloronitrobenzenes, solid or liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods	Crystallise the nitrobenzene from 95% EtOH (charcoal) and sublime it in vacuo. [Emmons JAm Chem Soc 76 3470 1954, Newman & Forrest J Am Chem Soc 69 1221 1947, Beilstein 5 IV 723.]
Incompatibilities	A strong oxidizer. Reacts violently with oxidizers, combustibles, alkalis, sodium methoxide; and reducing materials.
Waste Disposal	Incineration (816℃, 0.5 second for primary combustion; 1204℃, 1.0 second for secondary combustion). The formation of elemental chlorine can be prevented through injection of steam or methane into the combustion process. nitrogen oxides may be abated through the use of thermal or catalytic devices.

4-Chloronitrobenzene Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Sulfuric acid-->Nitric acid-->Chlorobenzene-->2-Nitrochlorobenzene

Preparation Products

Norfloxacin-->Albendazole-->4-Aminodiphenylamine-->2-Amino-5-chlorobenzophenone-->1-(4-ISOCYANATOPHENYL)-4-METHYLPIPERAZINE-->3,4-Dichloroaniline-->Phenetidine-->Sodium 4-nitrophenoxide-->Anilofos-->1-Chloro-3-nitrobenzene-->4-(4-Methylpiperazino)aniline-->Propanil-->7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate-->Diuron-->6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE-->1-METHYL-4-(4-NITROPHENYL)PIPERAZINE-->4-Fluoronitrobenzene-->Demoxepam-->3,4-Dichloronitrobenzene-->4-NITROPHENYL PHENYL ETHER-->Itraconazole-->2-CHLORO-5-NITROBENZENESULFONIC ACID-->Sulfaguanidine-->Sodium 2-chloro-5-nitrobenzenesulfonate-->4-Fluorophenol-->4-Aminodiphenylamine-->Estazolam-->4-NITROPHENETOLE-->VARIAMINE BLUE B DIAZONIUM SALT-->4-(1-Acetylpiperazin-4-yl)phenol-->4-Diazodiphenylamine sulfate-->Disperse Blue 301-->NITROFEN-->5-CHLORO-3-PHENYLANTHRANIL-->4-Nitroanisole-->BIS(4-NITROPHENYL) SULFIDE-->Alprazolam-->4-Cyanotetrahydropyran-->4-ISOTHIOCYANATO-4'-NITRODIPHENYL ETHER-->4-[(4-methoxyphenyl)amino]benzenediazonium

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Basic Info

Product Name:

1-Chloro-4-nitrobenzene

Other Name:

Benzene,1-chloro-4-nitro-;1-Chloro-4-nitrobenzene;p-Chloronitrobenzene;4-Chloro-1-nitrobenzene;p-Nitrochlorobenzene;PNCB;p-Nitrophenyl chloride;4-Chloronitrobenzene;4-Nitrochlorobenzene;4-Nitro-1-chlorobenzene;1-Nitro-4-chlorobenzene;4-Nitrophenyl chloride;NSC 9792

CAS No.:

100-00-5

Molecular Formula:

C6H4ClNO2

InChIKeys:

InChIKey=CZGCEKJOLUNIFY-UHFFFAOYSA-N

Molecular Weight:

157.55400

Exact Mass:

157.55

EC Number:

202-809-6

HScode:

29049085

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

45.82000

XLogP3:

2.77140

Appearance:

P-nitrochlorobenzene is a light yellow crystalline solid. Density 1.520 g / cm3. Melting point 83°C. Sweet odor. Very toxic by inhalation, ingestion, and skin absorption.

Density:

1.520 g/cm³

Melting Point:

82-84 °C

Boiling Point:

242 °C @ Press: 760 Torr

Flash Point:

127ºC

Refractive Index:

1.5376 (100ºC)

Water Solubility:

H2O: Insoluble

Storage Conditions:

Store in a cool, dry place. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightl

Vapor Pressure:

0.09 mm Hg ( 25 °C)

Vapor Density:

5.4 (vs air)

Flammability characteristics:

Solid that does not burn, or burns with difficulty.

Odor:

Sweet odor

See More 1-Chloro-4-nitrobenzene Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 2

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled H341 Suspected of causing genetic defects H351 Suspected of causing cancer H373 May cause damage to organs through prolonged or repeated exposure H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from combustible substances, reducing agents and food and feedstuffs. Keep in a well-ventilated room.Store in cool, dry, well-ventilated location. Separate from alkalies and oxidizing materials.

See More 1-Chloro-4-nitrobenzene Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

12 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	1-Chloro-4-nitrobenzene	1000.00 KG	Mar 13, 2025
United Arab Emirates	p-Nitrochlorobenzene	20 MT	Mar 15, 2024
India	2,6 Naphthalenedicarboxylic acid	10.00 KG	Mar 14, 2025
India	Sodium chlorite	2000.00 KG	Mar 13, 2025
India	Morpholine	2000.00 KG	Mar 13, 2025
India	P-Chlorophenyl hydrazine HCL	1000.00 KG	Mar 13, 2025
India	N,N-disuccinimidyl carbonate	10.00 KG	Mar 14, 2025
India	Diethyl methyl malonte	800.00 KG	Mar 14, 2025
India	Sodium dihydrogen phosphate dihydrate	2500.00 KG	Mar 13, 2025
India	8-DM	5.00 KG	Mar 14, 2025
India	pentafluorobenzene	75.00 KG	Mar 14, 2025
India	4-Ethylaniline	100.00 KG	Mar 13, 2025

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