(R)-(-)-2-Amino-3-methylbutane | CAS 34701-33-2 | 98% Purity (ee 97%) | Chiral Primary Aliphatic Amine | Pharmaceutical Intermediate & Asymmetric Sy

1. Product Overview

(R)-(-)-2-Amino-3-methylbutane, CAS 34701-33-2, is the (R)-enantiomer of 3-methyl-2-butylamine, a chiral primary aliphatic amine with molecular formula C₅H₁₃N and MW 87.16 g/mol. Also known as (R)-(-)-3-methyl-2-butylamine or ChiPros-grade AMP derivative, it appears as a clear, colorless to pale yellow liquid at 20°C with a characteristic amine odor. It is optically active with specific rotation [α]/D −5.5±1° (neat). This compound is air-sensitive and highly flammable (flash point <21°C), miscible with water (≈60 g/L at 20°C) and common organic solvents. It serves as a key chiral building block in asymmetric synthesis, pharmaceutical intermediate preparation, and resolution of diastereomeric salts.

2. Key Features and Advantages

• High Enantiomeric Purity — ChiPros grade: ≥98% chemical purity with ee ≥97%, suitable for stereoselective synthesis.

• Defined Chirality — (R)-configuration with verified optical rotation (−5.5° neat), essential for enantiomer-specific bioactivity.

• Versatile Reactivity — Primary amine functionality enables amidation, reductive amination, salt formation, and ligand/scaffold construction.

• Broad Solubility — Miscible with water and soluble in alcohols, ethers, hydrocarbons; ideal for multi-phase reaction systems.

• Established GMP Sourcing — Available from qualified suppliers for pharma R&D and custom synthesis pipelines.

3. Main Applications

4. Technical Specifications

5. Storage and Handling

• Storage Conditions: Store in a cool, dry, well-ventilated area below 25°C, away from heat/open flames (flash point <21°C). Keep container tightly sealed under inert atmosphere (N₂ or Ar) to prevent oxidation and moisture uptake. Recommended: refrigerator (2–8°C) for long-term storage.

• Packaging Options: Research scale: 100 mg / 500 mg / 1 g / 5 g / 25 g amber vials with septum caps; bulk: 100 g / 500 g / 1 kg / 5 kg upon custom synthesis request.

• Shelf Life: Stable for ≥12 months when stored unopened under inert atmosphere at 2–8°C; open vial should be used promptly.

• Handling Precautions: Use in fume hood with adequate ventilation. Wear nitrile gloves, safety goggles, flame-resistant lab coat. Avoid inhalation of vapors and skin/eye contact. Use spark-proof tools (flammable liquid, Class 3 PG II). Ground containers during transfer to prevent static discharge.

• Incompatible Materials: Strong oxidizers, acids, isocyanates, epoxy resins; keep away from ignition sources.

6. Safety Overview

In case of contact: skin—wash with plenty of water/soap; eyes—rinse 15 min, seek medical aid; inhalation—move to fresh air. Dispose per hazardous flammable corrosive waste rules.