Biotin

1H-Thieno[3,4-d]imidazole-4-pentanoic acid,hexahydro-2-oxo-,(3aS,4S,6aR)-;Biotin;1H-Thieno[3,4-d]imidazole-4-pentanoic acid,hexahydro-2-oxo-,[3aS-(3aα,4β,6aα)]-;(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid;Bioepiderm;Coenzyme R;Factor S;(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid;cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;Vitamin H;Vitamin B7;d-Biotin;(+)-Biotin;Factor S (vitamin);D(+)-Biotin;Bios II;D-Biotin;Meribin;Rovimix H 2;Lutavit H2;Biodermatin;NSC 63865;Vitamin I;Medebiotin;5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;MD 1003;7: PN: KR2178813 SEQID: 7 claimed sequence;3672-05-7;15720-24-8;22879-79-4;58073-87-3

58-85-5

C10H16N2O3S

InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N

244.31

244.31

200-399-3

6SO6U10H04

DTXSID7022679

C309

Long, thin needles from water|Colorless, crystalline

A - Alimentary tract and metabolism

29362930

Other Food Additives

104

0.3

White powder

1.42 g/cm³

232 °C (decomp)

573.6ºC at 760 mmHg

300.7ºC

90.5 ° (C=2, 0.1mol/L NaOH)

Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.

Capsules and Tablets: Store below 40 deg C (104 deg F), preferably between 15 and 30 deg C (59 and 86 deg F), unless otherwise specified by manufacturer.

1.07X10-8 mm Hg at 25 deg C (est)

LD50 orally in Rabbit: > 2000 mg/kg

Henry's Law constant = 1.1X10-16 atm-cu m/mol at 25 °C (est)

150.4 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|152.96 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|154.16 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|164.45 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|159.72 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|149.7 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|160.1 Ų [M+K]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|159.9 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|155.4 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|152.9 Ų [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|148 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|152.9 Ų [M-2H+Na]-

Fine long needles. Melting point: 232-3 °C. pH 0.01% aq soln: 4.5. Isoelectric point pH: 3.5. Solubility in water, 2.20X10+2 mg/L at 25 °C. More sol in hot water and dil alkali; in 95% alc about 80 mg/100 ml at 25 °C; insol in other common org solvents. Specific optical rotation +91 deg at 21 °C (c=1, 0.1 N NaOH). The pure compd is stable to air and temp /Milk or liver biotin/|Water solutions are stable at 100 °C, and the dry substance is both thermostable and photostable. Biotin is unstable, however, in strong acids and alkaline solutions and in oxidizing agents.|Hydroxyl radical reaction rate constant = 4.0X10-11 cu cm/molec-sec at 25 °C (est)