Dihexa/DI10/improve the memory/99% high-purity/10mg/fast and safe delivery/on-time shipment|/reasonable price
TDS 36 Inquiries
129954-34-3
Cosmetics Grade
99.9%
XiangGang
DS
5mg*10vials 10mg*10vials 20mg*10vials 30mg*10vials 40mg*10vials
2026-09-04
Medical and health products,Peptide products,Chemical organic, drug intermediate
-
Product Description
-
Seller Information
-
Inquiry History
-
DescriptionECHEMI Editorial ReferenceSelank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genesIl2rgandXcr1in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.
SELANK Synthetic is a single, non-glycosylated polypeptide chain containing 7 amino acids, having a molecular mass of 751.89 Dalton and a Molecular formula of C33H57N11O9.Certificates-
TDS
Basic Info-
Product Name:
Selank peptide
Other Name:Selank peptide;SelankAcetate;PL14736;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline;L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE; MONOACETATE;H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH;SLANK;Selank peptid
CAS No.:129954-34-3
Molecular Formula:C33H57N11O9
InChIKeys:JTDTXGMXNXBGBZ-YVHUGQOKSA-N
Molecular Weight:751.87
Exact Mass:751.43407244
EC Number:232-660-2
UNII:TS9JR8EP1G
Categories:
Characteristics-
Density:
1.53±0.1 g/cm3(Predicted)
Melting Point:134-136 °C
PKA:3.43±0.20(Predicted)
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
Medical and health products,Peptide products,Chemical organic, drug intermediate
-
Location:
Room 210, 2nd Floor, Office Building No.1, Dezhou Fushite Electric Motor Co., Ltd., North of Xiaoli Road and West of Tianlong Village, Tianqu Sub-district Office
-
Payment Terms:
100% TT in advance
-
Average lead Time:
15 days
-
Total Annual Revenue:
$5 million-$10 million
-
Total Employees:
51-100
-
Year of Establishment:
2026
Company Certificates-
COA
-
COA
-
-
Inquiry History36 Inquiries
Country Product Purchase Quantity Date Posted
United States
Selank 99% Purity 129954-34-3
1 G Jan 23, 2026
United States
Selank peptide
10 MG Sep 18, 2026
Greece
selank
10 MG May 20, 2026
United States
N acetyl selank
500 MG Apr 30, 2026
United States
Selank
100 MG Apr 24, 2026
Italy
Nacetyl selank
1 MT Apr 22, 2026
Oman
Selank
1 G Mar 4, 2026
United States
Selank
30 40' Fcl Oct 14, 2025
United States
selank
30 MG May 25, 2026
Brazil
Selank
10 MT Apr 7, 2026
United States
selank
1 G Mar 13, 2026
United States
Selank
1 G Mar 9, 2026
United Kingdom
Selank
1 G Dec 22, 2025
United States
Selank
20 MG Nov 10, 2025
United States
NA-Selank Amidate
10 MG Sep 18, 2025
United Kingdom
Selank
100 MG Jul 15, 2025
United States
N-Acetyl Selank Amidate
1 KG Jan 9, 2025
United States
Selank
10 Mar 29, 2024
Poland
Selank
10 G Feb 18, 2024
United States
Selank
1 G Jan 27, 2024 Post an enquiry for this product
More from this Seller
-
-
-
KPV Manufacturer High Purity Lyophilized Powder CAS Number 67727-97-3 Peptide
Industrial Grade / 99.99%
$40/UNIT FOB
-
-
-
-
China Factory Direct Supply NAD High Quality Peptide NAD+ for Research use
Industrial Grade / 99.99%
$40/UNIT FOB
-
-
-
-
FOXO4 Factory Price Peptide Powder High Quality In stock F410 CAS:2460055-10-9
Industrial Grade / 99.99%
$300/UNIT FOB
-
-
-
-
AOD/Direct supply from the manufacturer. Quality control. Official testing. Sold worldwide.
Industrial Grade / 99.9%
-
-
-
-
NAD 1000/Direct supply from the manufacturer. Quality control. Official testing. Sold worldwide.
Industrial Grade / 99.9%
$30/UNIT FOB
-
-
-
-
LC120| LC600 | LC216 | LC526 Purity 99% L-Carn itine Lyophilized Powder | Peptide Raw Material | Wholesale Price
Industrial Grade / 99.99%
$60/UNIT FOB
-