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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Dasatinib for Sale > Dasatinib CAS 302962-49-8 Multitargeted Tyrosine Kinase Inhibitor for CML and ALL Research hfd
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Dasatinib CAS 302962-49-8 Multitargeted Tyrosine Kinase Inhibitor for CML and ALL Research hfd

TDS 4 Inquiries

Unit Price:

$100-130/G FOB

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CAS No.:

302962-49-8

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-28

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Dasatinib BMS-354825; Sprycel
    CAS Number 302962-49-8 302962-49-8
    Molecular Formula C₂₂H₂₆ClN₇O₂S —
    Molecular Weight 488.01–488.06 g/mol
    Appearance White to off-white to beige powder Visual inspection 
    Purity ≥98.0% Determined by HPLC 
    Melting Point 275–286°C
    Solubility DMSO: 2–50 mg/mL; DMF: 25 mg/mL; H₂O: 0.0051 mg/mL
    Ki (Src) 16 pM Potent Src inhibition 
    Ki (Bcr-Abl) 30 pM Potent Bcr-Abl inhibition 
    Storage -20°C, sealed, inert atmosphere, protect from light and moisture Air-sensitive, heat-sensitive 
    Packaging 5mg, 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Oncology research, kinase inhibition studies


    —— Product Detail ——

    Product Overview

    • Dasatinib (CAS 302962-49-8), also known as BMS-354825 and marketed under the brand name Sprycel, is a highly potent, ATP-competitive, orally active multitargeted tyrosine kinase inhibitor with significant antitumor activity . It appears as a white to off-white to beige powder with the molecular formula C₂₂H₂₆ClN₇O₂S and a molecular weight of approximately 488 g/mol . Its IUPAC name is N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Dasatinib (BMS-354825) is a dual Bcr-Abl and Src family tyrosine kinase inhibitor with IC50s of 0.6, 0.8, 79 and 37 nM for Abl, Src, c-Kit and c-KitD816V, respectively.
    Solid
    Dasatinib (anhydrous) is an aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). It has a role as a tyrosine kinase inhibitor, an anticoronaviral agent and an antineoplastic agent. It is a secondary amino compound, a tertiary amino compound, an organochlorine compound, an aminopyrimidine, a member of 1,3-thiazoles, a monocarboxylic acid amide, a N-arylpiperazine and a N-(2-hydroxyethyl)piperazine.|Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.|Dasatinib anhydrous is a Kinase Inhibitor. The mechanism of action of dasatinib anhydrous is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor.|Dasatinib is a selective tyrosine kinase receptor inhibitor that is used in the therapy of chronic myelogenous leukemia (CML) positive for the Philadelphia chromosome. Dasatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.|Dasatinib Anhydrous is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.|A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB.

    Certificates
    • Dasatinib CAS 302962-49-8 Multitargeted Tyrosine Kinase Inhibitor for CML and ALL Research hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Dasatinib

    Other Name:

    5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-;N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide;BMS 354825;Dasatinib;BMS 35482513;Sprycel;Spyrcel;BMS 345825;KIN 001-5;NSC 759877

    CAS No.:

    302962-49-8

    Molecular Formula:

    C22H26ClN7O2S

    InChIKeys:

    InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N

    Molecular Weight:

    488.007

    Exact Mass:

    488.01

    EC Number:

    801-607-0

    UNII:

    X78UG0A0RN

    NSC Number:

    759877|732517

    DSSTox ID:

    DTXSID4040979

    NCI Thesaurus Code:

    C74556

    ATC Code:

    L01EA02|L01XE06|L - Antineoplastic and immunomodulating agents

    HScode:

    29341000

    Characteristics
    PSA:

    135

    XLogP3:

    3.6

    Appearance:

    Solid

    Density:

    1.4±0.1 g/cm3

    Melting Point:

    280 - 286 °C

    Refractive Index:

    1.688

    Water Solubility:

    1.28e-02 g/L

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Skin irritation, Category 2

    Serious eye damage, Category 1

    Carcinogenicity, Category 2

    Reproductive toxicity, Category 2

    Specific target organ toxicity – repeated exposure, Category 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H315 Causes skin irritation

    H318 Causes serious eye damage

    H351 Suspected of causing cancer

    H361 Suspected of damaging fertility or the unborn child

    H372 Causes damage to organs through prolonged or repeated exposure

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P203 Obtain, read and follow all safety instructions before use.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P317 Get medical help.

    P318 IF exposed or concerned, get medical advice.

    P319 Get medical help if you feel unwell.

    P391 Collect spillage.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    4 Inquiries
    Country Product Purchase Quantity Date Posted
    Pakistan

    DASATINIB

    500 G Aug 29, 2025
    Jordan

    Dasatinib

    1.00 KG Sep 20, 2023
    Canada

    Dasatinib

    500 MG Mar 4, 2025
    India

    Dasatinib

    100.00 KG Nov 7, 2023
    Post an enquiry for this product
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