β-Lapachone
4707-32-8
Pharma Grade
99%
DAHAI BIOCHEM
25kg/Cardboard Drum
2026-12-31
HARD FAT
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Product Description
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Seller Information
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DescriptionECHEMI Editorial Referenceβ-Lapachone is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
Beta-lapachone is a benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities. It has a role as an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is a benzochromenone and a member of orthoquinones.|Lapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.|Lapachone is a poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. Beta-lapachone (b-lap) is bioactivated by NAD(P)H:quinone oxidoreductase-1 (NQO1), creating a futile oxidoreduction that generates high levels of superoxide. In turn, the highly reactive oxygen species (ROS) interact with DNA, thereby causing single-strand DNA breaks and calcium release from endoplasmic reticulum (ER) stores. Eventually, the extensive DNA damage causes hyperactivation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme facilitating DNA repair, accompanied by rapid depletion of NAD+/ATP nucleotide levels. As a result, a caspase-independent and ER-stress induced mu-calpain-mediated cell death occurs in NQO1-overexpressing tumor cells. NQO1, a flavoprotein and two-electron oxidoreductase, is overexpressed in a variety of tumors.Basic Info-
Product Name:
β-Lapachone
Other Name:2H-Naphtho[1,2-b]pyran-5,6-dione,3,4-dihydro-2,2-dimethyl-;3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione;β-Lapachone;SL 11001;NSC 26326;NSC 629749;ARQ 501;MB 12066;2,2-Dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione
CAS No.:4707-32-8
Molecular Formula:C15H14O3
InChIKeys:InChIKey=QZPQTZZNNJUOLS-UHFFFAOYSA-N
Molecular Weight:242.27
Exact Mass:242.27
UNII:6N4FA2QQ6A
NSC Number:629749|26326
DSSTox ID:DTXSID90197019
NCI Thesaurus Code:C28694
HScode:2914399090
Categories:
Characteristics-
PSA:
43.4
XLogP3:2.2
Density:1.3±0.1 g/cm3
Melting Point:124.5-125.5 °C
Boiling Point:381.4ºC at 760 mmHg
Flash Point:169.7±27.9 °C
Refractive Index:1.595
Storage Conditions:-20°C Freezer
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
HARD FAT
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Location:
BUILDING 4,NO.571, STR.19,BAIYANG DISTRICT, HANGZHOU,CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Total Annual Revenue:
Less than $1 million
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Total Employees:
5-10
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Year of Establishment:
2025
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