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Apigenin520-36-5

Name: Apigenin520-36-5
Brand: OORENT
SKU: pr2607031858
Price: 33 USD
Availability: InStock

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CAS No.:

520-36-5

Grade:

Industrial Grade

Content:

99%

Port:

上海

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-08-03

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Apigenin Basic information

Description

Product Name:	Apigenin
Synonyms:	5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone;4,5,7-Trihydroxyflavone (apigenin);APIGENIN CRYSTALLINE;APIGENIN FROM PARSLEY;Matricaria chamomilla flower;Versuline;Pelargidenon 1449;4’,5,7-trihydroxyflavaone
CAS:	520-36-5
MF:	C15H10O5
MW:	270.24
EINECS:	208-292-3
Product Categories:	cosmetic;natural product;chemical reagent;pharmaceutical intermediate;Plant extract;pyridine series;Tri-substituted Flavones;Inhibitors;Protein Kinase;Signalling;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;CITRIMORE;Biochemistry;Flavonoids;Natural Plant Extract;520-36-5
Mol File:	520-36-5.mol

Apigenin Chemical Properties

Melting point	>300 °C (lit.)
Boiling point	333.35°C (rough estimate)
density	1.2319 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	DMSO: 27 mg/mL
form	powder
pka	6.53±0.40(Predicted)
color	yellow
biological source	parsley
Merck	14,730
BRN	262620
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Major Application	food and beverages
Cosmetics Ingredients Functions	ANTIOXIDANT HAIR CONDITIONING
InChI	InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChIKey	KZNIFHPLKGYRTM-UHFFFAOYSA-N
SMILES	C1(C2=CC=C(O)C=C2)OC2=CC(O)=CC(O)=C2C(=O)C=1
LogP	3.020
CAS DataBase Reference	520-36-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	LK9276000
F	10
HS Code	29329985
Storage Class	11 - Combustible Solids
Hazardous Substances Data	520-36-5(Hazardous Substances Data)

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Apigenin Usage And Synthesis

Description	Apigenin(520-36-5) is one of the most widespread flavonoids in plants and formally belongs to the flavone sub-class. Of all the flavonoids, apigenin is one of the most widely distributed in the plant kingdom, and one of the most studied phenolics. Apigenin is present principally as glycosylated in significant amount in vegetables (parsley, celery, onions) fruits (oranges), herbs (chamomile, thyme, oregano, basil), and plant-based beverages (tea, beer, and wine). Plants belonging to the Asteraceae, such as those belonging to Artemisia, Achillea, Matricaria, and Tanacetum genera, are the main sources of this compound.
Chemical Properties	Pale Yellow Crystalline Solid
Uses	Apigenin is an active antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective and cognitive enhancing substance with interesting potential in the treatment/prevention of Alzheimer's disease.
Uses	Apigenin has been shown to possess antibacterial, antiviral, antifungal, and antiparasitic activities. Although it can’t stop all types of bacteria on its own, it can be combined with other antibiotics to increase their effects.
Uses	Apigenin is a promising reagent for cancer therapy. Apigenin appears to have the potential to be developed either as a dietary supplement or as an adjuvant chemotherapeutic agent for cancer therapy.
Definition	ChEBI: Apigenin is a trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells. It has a role as a metabolite and an antineoplastic agent. It is a conjugate acid of an apigenin-7-olate.
Preparation	4-hydroxybenzaldehyde (1.22 g, 9.97 mmol, 1.0 equiv) was added to asolution of 50% KOH (aq.) (6.72 g, 59.82 mmol, 6.0 equiv) and ethanol (3 mL) andstirred for 10 min. Then compound 9 (2.02g, 9.97 mmol, 1.0 equiv) was added to the reaction mixture and heated to 60 °C and stirred for 4 h. After cooled toroom temperature, the mixture was poured into ice water and acidified withconcentrated hydrochloric acid to pH = 3. Then the suspension was filtrated, washed and the residue was dried toafford Apigenin(2.43 g, 90%) as a red solid.
benefits	Apigenin has various beneficial health effects such as antioxidant, anti-inflammatory, and chemoprevention. Apigenin can downregulate the expression of IL-1β and TNF-α in LPS-stimulated mouse macrophages and human monocytes. preclinical studies have suggested that apigenin may improve outcomes in multiple health states, including anxiety, brain function, oxidative stress, inflammation, and hormonal regulation (testosterone, estrogen, and cortisol
Biological Activity	Cell permeable: no', 'Primary Target MAP kinase', 'Product does not compete with ATP.', 'Reversible: no
Mechanism of action	Apigenin exerts anxiolytic effects at high doses by inhibiting NMDA receptors; it also has affinity to GABA-A receptors. Apigenin also exerts potent antioxidant activities by scavenging free radicals and upregulating glutathione levels; it also exerts anti-inflammatory effects. Apigenin is most studied for its potential anti-cancer properties.
Anticancer Research	It induces apoptosis by targeting leptin/leptin receptor pathway and by targeting caspase-dependent extrinsic pathway aswell as STAT3 signaling pathway in lung adenocarcinoma and BT-474 breast cancercells, respectively. It shows antitumor activity against breastcancer MCF-7 cells and colon cancer HCT 116 cells and is a mediator of cancerchemoprevention and an inducer of autophagy. It can be used to treat colon canceras it induces apoptosis in colon cancer cells. It also increase melanogenesis in B16cells by activating the p38 MAPK pathway.
Safety	Apigenin is considered safe when consumed in normal amounts through a diet rich in fruits, vegetables, and herbs. However, supplement doses tend to deliver a significantly higher amount of apigenin than would be generally consumed via dietary means. Higher doses of apigenin can cause stomach discomfort, and people should cease using it immediately and consult medical professionals. At high doses, it can trigger muscle relaxation and sedation[1]. Allergic reactions can also occur as a response to chamomile tea or apigenin.
Source	Apigenin (4′,5,7-trihydroxyflavone) is one of the most widespread flavonoids in plants and formally belongs to the flavone sub-class. Plants belonging to the Asteraceae, such as those belonging to Artemisia, Achillea, Matricaria, and Tanacetum genera, are the main sources of this compound. However, species belonging to other families, such as the Lamiaceae, for instance, Sideritis and Teucrium, or species from the Fabaceae, such as Genista, showed the presence of apigenin in the aglycone form and/or its C- and O-glucosides, glucuronides, O-methyl ethers, and acetylated derivatives. In gymnosperms, apigenin derivatives are mostly present in dimeric forms, with apigenin residues variously coupled, e.g., with CC linkage as in cupressuflavone and amentoflavone (I-8, II-8″ and I-3′, II-8″, respectively), or C—O linkage (I-4′, II-6″) as in hinokiflavone.
storage	+4°C
Purification Methods	The current method for the purification of apigenin is crude-solvent extraction method by using solvent in small quantity and also time saving. Apigenin that was isolated from Symphyotrichum novae-angliae was obtained in large quantity and directly from extract.
References	[1] Bahare Salehi, et al. “The Therapeutic Potential of Apigenin.” Int J Mol Sci. 2019 Mar; 20(6): 1305.

Apigenin Preparation Products And Raw materials

Preparation Products

Licoflavone C-->APIGENINTRIACETATE

Pls input... Shop TRANS-2-DECEN-1-OL18409-18-2-Detailed Image 2

Basic Info

Product Name:

Apigenin

Other Name:

4H-1-Benzopyran-4-one,5,7-dihydroxy-2-(4-hydroxyphenyl)-;Flavone,4′,5,7-trihydroxy-;5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Apigenin;Chamomile;C.I. Natural Yellow 1;4′,5,7-Trihydroxyflavone;Apigenine;Apigenol;5,7,4′-Trihydroxyflavone;LY 080400;UCCF 031;Pelargidenon 1449;Apegenin;Versulin;NSC 83244;5,7-Dihydroxy-2-(4-hydroxyphenyl)chromen-4-one;5,7-Dihydroxy-2-p-hydroxyphenyl-4-chromenone;ST 056301;461015-54-3

CAS No.:

520-36-5

Molecular Formula:

C15H10O5

InChIKeys:

InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N

Molecular Weight:

270.23700

Exact Mass:

270.24

EC Number:

926-224-7

UNII:

7V515PI7F6

NSC Number:

83244

DSSTox ID:

DTXSID6022391

Color/Form:

Yellow needles from aqueous pyridine

HScode:

2942000000

Categories:

Plant Extracts

Characteristics

PSA:

90.90000

XLogP3:

1.7

Appearance:

Solid

Density:

1.548 g/cm3

Melting Point:

347.5 °C

Boiling Point:

555.5ºC at 760 mmHg

Flash Point:

217ºC

Refractive Index:

1.732

Water Solubility:

DMSO: 27 mg/mL;In water, 183 mg/L at 25 deg C (est)

Storage Conditions:

-20ºC

Vapor Pressure:

1.01X10-10 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 5.12X10-17 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 7.12 (phenol); pKa2 = 8.10 (phenol) (est)

Collision Cross Section:

156 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Hydroxyl radical reaction rate constant = 2.31X10-10 cu cm/molec-sec at 25 °C (est)|Ozone reaction rate constant = 1.05X10-16 cu cm/molec sec at 25 °C (est)

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Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Apigenin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

13 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	98% Apigenin powder	10 KG	Sep 4, 2024
France	Apigenin	10 KG	Oct 24, 2025
Vietnam	Chamomile Extract 98% apigenin powder	120 KG	Jan 10, 2024
Germany	Professional manufacturer supply Citrus grandis (L.) Osbeck extract Apigenin 98%	40 MT	Oct 25, 2023
United Kingdom	Apigenin Luteolin	1 KG	Jul 3, 2026
India	Apigenin	10 G	May 22, 2026
India	Apigenin	1.00 KG	Mar 2, 2026
India	apigenin powder 98%	1 KG	Jan 19, 2026
Australia	Apigenin	1 KG	Nov 15, 2024
United States	Apigenin	4000 KG	Oct 10, 2024
Mexico	Apigenin	10 G	Sep 21, 2024
Chile	Apigenin	25 KG	Mar 26, 2024
Indonesia	APIGENIN	500 G	Nov 21, 2025

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