Berberine Hydrochloride 97.8% Purity Natural Isoquinoline Alkaloid Salt Reference Standard CAS 633-65-8 HPLC Grade

Product Overview
Berberine hydrochloride is the hydrochloride salt form of berberine, a naturally occurring isoquinoline alkaloid found in Coptis, Berberis, and Hydrastis species. It is supplied as a high-purity reference standard (HPLC≥97.8%) for phytochemical and pharmacological research. The salt form offers improved water solubility compared to the free base.

Synthetic Process
The compound is obtained from natural plant sources through solvent extraction followed by salt formation and multi-step chromatographic purification, including preparative HPLC, to achieve high purity.

Mechanism of Action
As an isoquinoline alkaloid salt, Berberine hydrochloride is used as a research tool for studying alkaloid biosynthesis, enzyme interactions, and cellular signaling pathways. It exhibits improved solubility for biological assays; specific data should be confirmed against current literature.

Quality Specifications

• Purity: ≥97.8% (HPLC)

• Identity confirmed by NMR and MS

• Appearance: yellow to orange-yellow crystalline powder

• Batch-specific Certificate of Analysis (COA)

• Stable when sealed and protected from light and moisture

Packaging & Storage
Available in 20mg, 50mg, 100mg and 1g amber glass vials. Store at 2–8°C, protected from light and moisture. Shelf life 24 months.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.