99% Purity Gentamicin Sulphate CAS 1405-41-0 Veterinary Use for Animal Infection Diseases

Physical and Chemical Properties: It appears as a white or almost white powder. It is freely soluble in water, practically insoluble in alcohol, ether and other organic solvents. Its pH value is between 3.5 and 5.5 (0.1% in H2O), and it has a melting point of 218 - 237ºC. It is chemically stable and relatively stable to temperature and pH changes.
Production Method: It is a multi - component aminoglycoside antibiotic produced by Micromonospora, and is usually prepared based on Micromonospora purpurea (actinomycete).

Pharmacological Action: It can bind to the 30S subunit of bacterial ribosomes, blocking the transfer of peptidyl - tRNA from the acceptor site to the donor site and causing a codon misreading, thus blocking bacterial protein synthesis and destroying the integrity of the bacterial cell membrane to play a bactericidal role.

Therapeutic Uses: It is a broad - spectrum antibiotic, mainly used to treat systemic or local infections caused by gram - negative bacteria, such as Escherichia coli, Shigella, Klebsiella pneumoniae, Proteus, Pseudomonas aeruginosa, etc. It is also used in ophthalmology for conjunctivitis, keratitis, etc. Orally, it can be used for intestinal infections or colon surgery preparation; it can also be used in combination with metronidazole.

In general, Gentamycin Sulfate has a wide range of applications in the medical field, but due to the emergence of resistant strains, its use needs to be rational and standardized.