 Home > Encyclopedia > 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione structure

CAS No:
133052-90-1
Formula:
C25H24N4O2
Chemical Name:
3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Synonyms:
1H-Pyrrole-2,5-dione,3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;GF 109203X;Go 6850;Bisindolylmaleimide I;BIM 1;Bis(indolyl)maleimide 1;GF 109203;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrol-2,5-dione;634199-82-9;682340-45-0
Categories:
Biochemical Engineering > Inhibitors

Description

Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM.

3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione Basic Attributes

Molecular Weight：

412.48

Exact Mass：

412.48

EC Number：

603-702-0

UNII：

L79H6N0V6C

DSSTox ID：

DTXSID50157932

Characteristics

PSA：

70.1

XLogP3：

3.1

Density：

1.3±0.1 g/cm3

Melting Point：

280 °C (decomp)

Boiling Point：

685.6°C at 760 mmHg

Flash Point：

368.5±31.5 °C

Refractive Index：

1.687

Water Solubility：

Insoluble in water.DMSO:~1 mg/mlsoluble

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

40-22

safety instructions：

36/37

RTECS Number：

UX9590000

Marks：

Precautionary statement(s)：

P281

Hazard Statements：

H302-H351

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

2-(1-(3-dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide

Computed Properties

Molecular Weight:412.5
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:412.18992602
Monoisotopic Mass:412.18992602
Topological Polar Surface Area:70.1
Heavy Atom Count:31
Complexity:748
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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Pharmaceutical Chemical Anti-hair loss GF109203X CAS NO 133052-90-1 in stock 99% white powder

CAS No.: 133052-90-1

Grade: Pharmaceutical Grade

Content: 99%

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Bisindolylmaleimide I

CAS No.: 133052-90-1

Content: 99.00%

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Guide of 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Recommended Suppliers
Latest News
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3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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