3-(Trimethylsilyl)-2-propyn-1-ol
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3-(Trimethylsilyl)-2-propyn-1-ol
structure -
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CAS No:
5272-36-6
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Formula:
C6H12OSi
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Chemical Name:
3-(Trimethylsilyl)-2-propyn-1-ol
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Synonyms:
2-Propyn-1-ol,3-(trimethylsilyl)-;3-(Trimethylsilyl)-2-propyn-1-ol;(3-Hydroxy-1-propynyl)trimethylsilane;3-(Trimethylsilyl)propargyl alcohol;1-(Trimethylsilyl)-1-propyn-3-ol;Hydroxymethyl(trimethylsilyl)acetylene;NSC 617397;Trimethylsilylpropargyl alcohol;3-Trimethylsilylyprop-2-ynol
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CAS No:
3-(Trimethylsilyl)-2-propyn-1-ol Basic Attributes
128.24
128.24
1902505
226-094-5
617397
DTXSID8063751
2931900090
Characteristics
20.2
0.85950
Clear yellow Liquid
0.875 g/cm3
63.5-65.0 °C
170-172 °C
152 °F
n20/D 1.451(lit.)
Not miscible with water.
2-8°C
Safety Information
III
6.1
2810
3
36/37/38
23-24/25-37/39-26
Xi
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H301
|Danger|H227 (20%): Combustible liquid [Warning Flammable liquids]|P210, P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3-(Trimethylsilyl)-2-propyn-1-ol Use and Manufacturing
In a flask containing methanol (4.0 mL) and Amberlyst-15 (0.025 g) under NExample 40; 3-(Trimethylsilyl)prop-2-yn-1-ol; n-BuLi (27.3 mL, 44 mmol, 2.2 eq.) was added dropwise to a stirred solution of 2-propyn-1-ol (1.16 mL, 20 mmol, 1 eq.) in THF (60 mL) at -78° C. under argon. After 20 minutes, trimethylsilyl chloride (52 mL, 60 mmol, 2 eq.) was added dropwise and the mixture allowed to warm to room temperature. 2M HCl (40 mL) was added at 0° C., and the reaction mixture was stirred at room temperature for 16 hours. The organic layer was separated and the aqueous layer extracted with EtA cold (-50 °C) solution of ether 1 (10.2 g, 0.08 mol) in anhydrous THF (50 mL) was added to a solution of Bu
2-Propyn-1-ol, 3-(trimethylsilyl)-: ACTIVE
Computed Properties
Molecular Weight:128.24
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:128.065741536
Monoisotopic Mass:128.065741536
Topological Polar Surface Area:20.2
Heavy Atom Count:8
Complexity:120
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-(Trimethylsilyl)-2-propyn-1-ol
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