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Diltiazem

Diltiazem structure

CAS No:
42399-41-7
Formula:
C22H26N2O4S
Chemical Name:
Diltiazem
Synonyms:
1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-;1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S-cis)-;(2S,3S)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one;Diltiazem;d-cis-Diltiazem;(+)-cis-Diltiazem;(+)-Diltiazem;d-Diltiazem;Dilzem;Coras;Adizem XL;Cartia XT;Balcor;Dilzem retard;Diltia XT
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

ChEBI: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the m nagement of angina pectoris and hypertension.

Diltiazem Basic Attributes

Molecular Weight：

414.52

Exact Mass：

414.52

EC Number：

255-796-4

Characteristics

PSA：

84.38000

XLogP3：

3.63

Appearance：

Solid

Density：

1.3±0.1 g/cm3

Melting Point：

212 °C (decomp)

Boiling Point：

594.4±50.0 °C at 760 mmHg

Flash Point：

313.3±30.1 °C

Refractive Index：

1.621

Water Solubility：

1.68e-02 g/L

Storage Conditions：

Diltiazem hydrochloride injection in vials should be refrigerated at 2-8 deg C; freezing of the injection should be avoided. Diltiazem hydrochloride injection may be stored at room temp for up to 1 month; after that time, the injection should be discarded. Diltiazem hydrochloride powder for injection in single-use vials ... or in single-use syringes ... should be stored at a room temp of 15-30 deg C; freezing of the powder for injection should be avoided. Following reconstitution of diltiazem hy

Safety Information

Stability/Shelf Life：

The photostability of diltiazem was studied in aq solns at different pH values. Firstly, the hydrolysis of the drug to desacetyldiltiazem in alkaline medium was evaluated and then the drug photodegradation under exposure to UVA-UVB radiation (solar simulator) was monitored by HPLC methods. The main photoproduct was isolated and characterized as diltiazem-S-oxide on the basis of the NMR and mass spectra. The HPLC method was also applied to the selective analysis of diltiazem in commercial formula

Diltiazem Use and Manufacturing

Pharmaceutical intermediates