 Home > Encyclopedia > Piribedil

Piribedil

Piribedil structure

CAS No:
3605-01-4
Formula:
C16H18N4O2
Chemical Name:
Piribedil
Synonyms:
Pyrimidine,2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-;Pyrimidine,2-(4-piperonyl-1-piperazinyl)-;2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine;1-(2-Pyrimidyl)-4-piperonylpiperazine;4-[3,4-(Methylenedioxy)benzyl]-1-(2-pyrimidinyl)piperazine;ET 495;Piribedil;Trivastal;1-(2-Pyrimidyl)-4-(3,4-methylenedioxybenzyl)piperazine;Trivastan;EU 4200;Pronoran;2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR).

2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.|Piribedil has been investigated in Parkinson's Disease.|A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.

Piribedil Basic Attributes

Molecular Weight：

298.34

Exact Mass：

298.34

EC Number：

222-764-6

UNII：

DO22K1PRDJ

DSSTox ID：

DTXSID9045188

ATC Code：

N04BC08|N - Nervous system

HScode：

2934999090

Characteristics

PSA：

50.7

XLogP3：

1.8

Density：

1.3±0.1 g/cm3

Melting Point：

98 °C

Boiling Point：

469.4±55.0 °C at 760 mmHg

Flash Point：

237.7±31.5 °C

Refractive Index：

1.632

Toxicity：

LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)

Safety Information

RTECS Number：

UV9704000

Precautionary statement(s)：

P201, P260, P261, P263, P264, P270, P271, P273, P301+P312, P304+P340, P308+P313, P312, P314, P330, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P260, P261, P263, P264, P270, P271, P273, P301+P312, P304+P340, P308+P313, P312, P314, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)|Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

MeSH Entry Terms：

ET 495

Piribedil Use and Manufacturing

Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.

Computed Properties

Molecular Weight:298.34
XLogP3:1.8
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:298.14297583
Monoisotopic Mass:298.14297583
Topological Polar Surface Area:50.7
Heavy Atom Count:22
Complexity:356
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Dopaminergic agonists stimulate dopamine receptors and dopaminergic pathways in the brain, increase femoral artery blood flow, stimulate dopaminergic cortical electrophysiology during wakefulness and sleep, and control different clinical functions.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Piribedil extended-release tablets
Ingredients	The main ingredient of this product is piribedil. Chemical name: piribedil [(methylenedioxy-3, 4-benzyl)-4-piperazinyl-1]-2-pyrimidine Molecular weight: C16H18N4O2
Indication	1. Contraindications for combined use: (1) Tranquilizers (excluding clozapine) (in non-Parkinson's patients): There is an antagonism between dopamine agonists and neuroleptics. When extrapyramidal symptoms occur due to taking tranquilizers, patients should not use dopamine agonists for treatment, but should use anticholinergic drugs. (2) Antiemetics: There is an antagonism between dopamine agonists and neuroleptics. Antiemetics without extrapyramidal effects should be used. 2. Inappropriate combined use: Tranquilizers (excluding clozapine) (in non-Parkinson's patients): There is an antagonism between dopamine agonists and neuroleptics. Dopamine agonists can cause or aggravate mental disorders. If the
Specifications	50mg

Taysuda (piribedil extended-release tablets)
Ingredients	Each tablet of Taishu 50mg sustained-release coated tablet contains 50mg of piribedil. Chemical name: [(methylenetrioxy-3,4-benzyl)-4-piperazinyl-1]-2-pyrimidine Molecular weight: C16H18N4O2
Indication	Contraindications for combined use 1. Tranquilizers (excluding clozapine) (In non-Parkinson's patients) There is an antagonism between dopamine agonists and neuroleptics. When extrapyramidal symptoms occur due to taking tranquilizers, patients should not be treated with dopamine agonists, but anticholinergic drugs should be used. 2. Antiemetics There is an antagonism between dopamine agonists and neuroleptics. Antiemetics without extrapyramidal effects should be used. Inappropriate combined use 3. Tranquilizers (excluding clozapine) (In Parkinson's patients) There is an antagonism between dopamine agonists and neuroleptics. Dopamine agonists can cause or aggravate mental disorders. If you are currently using dopamine agonists for treatment
Specifications	50mg*15s

Piribedil extended-release tablets
Specifications	50mg

See More Related Drugs

Registered Holders

COHANCE LIFESCIENCES LTD

United States
Active
Kaifeng MINGREN Pharmaceuticals Co., Ltd.

China
Active
HeBei Guolong Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Piribedil

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Piribedil

CAS No.: 3605-01-4

Content: 99.00%

Inquiry
Dayang Chem (Hangzhou) Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol,N,N-Formylmorpholine,Epichlorohydrin,Tetramethylguanidine,Dimethicone,3

Piribedil Manufacturer/High quality/Best price/In stock

CAS No.: 3605-01-4

Content: 98%

Inquiry