 Home > Encyclopedia > Aniracetam

Aniracetam

Aniracetam structure

CAS No:
72432-10-1
Formula:
C12H13NO3
Chemical Name:
Aniracetam
Synonyms:
2-Pyrrolidinone,1-(4-methoxybenzoyl)-;1-(4-Methoxybenzoyl)-2-pyrrolidinone;Aniracetam;Ro 13-5057/001;Ro 13-5057;Draganon;Ro 13-3057;Sarpul;Ampamet;75878-25-0
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.Target: AMPA; nAChRAniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It selectively modulates the AMPA receptor. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects. It ha

Aniracetam is a member of pyrrolidin-2-ones and a N-acylpyrrolidine.|Compound with anti-depressive properties used as a mental performance enhancer.

Aniracetam Basic Attributes

Molecular Weight：

219.24

Exact Mass：

219.24

EC Number：

1308068-626-2

UNII：

5L16LKN964

NSC Number：

758223

DSSTox ID：

DTXSID5045128

ATC Code：

N - Nervous system

Characteristics

PSA：

46.6

XLogP3：

1.6

Appearance：

White Crystalline or Crystalline Powde

Density：

1.2±0.1 g/cm3

Melting Point：

121-122 °C

Boiling Point：

399.7±34.0°C at 760 mmHg

Flash Point：

195.5±25.7 °C

Refractive Index：

1.574

Water Solubility：

Soluble in chloroform. Also soluble in ethanol. Insoluble in water

Storage Conditions：

Store at RT

Vapor Density：

4.9 (vs air)

Toxicity：

LD50 in rats, mice (mg/kg): ~4500, >5000 orally (Cumin)

Collision Cross Section：

146.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

UY5781900

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

Pharmacology：

Aniracetam possesses a wide range of anxiolytic properties, which may be mediated by an interaction between cholinergic, dopaminergic and serotonergic systems.

MeSH：

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)|Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

Biological Half-Life：

1-2.5 hours

MeSH Entry Terms：

1-(4-methoxybenzoyl)-2-pyrrolidinone

Aniracetam Use and Manufacturing

Methods of Manufacturing

Into a 250 mL four-necked flask, 150 mL of toluene, p-methoxybenzoic acid (34 g, 0.2 mol), α-pyrrolidone (17 g, 0.2 mol), silica (6 g, 10 mmol) were refluxed, and methanol was distilled off. . Methanol was evaporated and cooled to 15°C to precipitate a solid. Filter to obtain a solid cake. Dissolve with 95percent ethanol, decolorize the activated carbon, filter it while hot, crystallization after cold, filter and filter cake to obtain dried aniracetam finished product 39.5g. (Yield is 91percent)General procedure: In a typical reaction, a round-bottom flask equipped with a Dean-Stark apparatus, a magnetic stirring bar and temperature controller was charged with 2-pyrrolidone (5.8 mmol), palmitic acid (5.8 mmol), ZrOCl

Uses

Cognition enhancer related to Piracetam. Nootropic.

Computed Properties

Molecular Weight:219.24
XLogP3:1.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:219.08954328
Monoisotopic Mass:219.08954328
Topological Polar Surface Area:46.6
Heavy Atom Count:16
Complexity:282
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

2-Pyrrolidone

Chlorotrimethylsilane

Thionyl chloride

Drug Function and Efficacy

This product is a brain function improving drug, which is a cyclized derivative of γ-aminobutyric acid (GABA). This product selectively acts on the central nervous system through the blood-brain barrier. Animal experiments have shown that this product has a good promoting effect on the memory reproduction process of normal rats' discrimination learning, can counteract the memory loss caused by hypoxia, and can effectively improve memory disorders caused by certain reasons.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Aniracetam Capsules
Ingredients	The main ingredient of this product is aniracetam, whose chemical name is 1-(4-methoxybenzoyl)-2-pyrrolidone.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.1g
Manufacturer	Hunan Warrant Pharmaceutical Co., Ltd.

Aniracetam Capsules
Ingredients	Aniracetam. Chemical name: 1-(4-methoxybenzoyl)-2-pyrrolidone.
Indication	Not yet clear.
Specifications	0.1g
Manufacturer	Wuxi Kaifu Pharmaceutical Co., Ltd.

Aniracetam Capsules
Ingredients	Aniracetam.
Indication	Not yet clear.
Specifications	0.1 g
Manufacturer	Wuxi Cathy Pharmaceuticals Ltd.

See More Related Drugs

Registered Holders

Hunan Warrant Chiral Pharmaceutical Co., Ltd.

China
Active
Shandong Newtime Pharmaceutical Co., Ltd.

China
Active
Jincheng Haisi Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Aniracetam

Conier Chem&Pharma Limited Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Dicobalt Octacarbonyl,(E,E)-Farnesol,(4S,5R)-4-Methyl-5-phenyloxazolidin-2-one,Geranyl linalool,farnesyl acetone

Aniracetam 1

CAS No.: 72432-10-1

Content: 99%

Inquiry
Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

High Purity Aniracetam CAS 72432-10-1 White Powder with Safety Delivery

CAS No.: 72432-10-1

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Eon Biotech Contact Supplier

GB
4 YRS

Business licensed

Trader Supplier of Nootropics,Sarms,Peptides,API,Intermediates

Aniracetam - 72432-10-1 - 98%

CAS No.: 72432-10-1

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
Yiling Wanyang Import and Export Co.,ltd Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier of Aspirin,Salicylic Acid

Aniracetam API

CAS No.: 72432-10-1

Inquiry
Huangshi pharma Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of OXALACETIC ACID,NIFUROXAZIDE,SODIUM STIBOGLACONATE,AMPIROXICAM,ALLOPURINOL,XYAZINE HCL,MEGLUMINEANTIMONATE

Aniracetam 99.99%

CAS No.: 72432-10-1

Grade: Pharmaceutical Grade

Content: 99.99%

Inquiry