2-Amino-6-methoxypyridine
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2-Amino-6-methoxypyridine
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CAS No:
17920-35-3
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Formula:
C6H8N2O
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Chemical Name:
2-Amino-6-methoxypyridine
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Synonyms:
6-Methoxy pyridine-2-amine;2-AMINO-6-METHOXYPYRIDINE;6-METHOXY-2-PYRIDINAMINE;6-METHOXY-2-PYRIDINAMINE HYDROCHLORIDE;6-METHOXY-2-PYRIDINEAMINE;6-METHOXY-2-AMINOPYRIDINE;6-METHOXYPYRIDIN-2-AMINE;6-METHOXY-PYRIDIN-2-YLAMINE
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CAS No:
Characteristics
48.1
1.6
Brown Liquid
1.139±0.06 g/cm3(Predicted)
115°C/13mmHg(lit.)
92.6±21.8 °C
1.5760-1.5800
Slightly soluble in water.
0-10°C
0.0694mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
22-36
26
Xi,Xn
P305 + P351 + P338
H302-H319
|Warning|H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Amino-6-methoxypyridine Use and Manufacturing
To a solution of Example 63 Synthesis of 2-(chloromethyl)-5-methoxyimidazo[1, 2-a]pyridine. A solution of 6-methoxypyridin-2-amine (500 mg, 4.1 mmol) and 1, 3-dichloropropan-2-one (2.58 g, 20.5 mmol) in DMF (10 mL) was stirred at 90 C. for 2 h. Then the reaction mixture was diluted with H2O (100 mL) and extracted with EtOAc (100 mL*3). The combined organic layers were dried over Na2SO4, concentrated and purified by column chromatography (CH2Cl2/MeOH=3/1) to give the desired product 2-(chloromethyl)-5-methoxyimidazo[1, 2-a]pyridine (200 mg, yield: 25%) as brown oil. ESI-MS [M+H]+: 197.1.General procedure: To a solution of 5-(2-chloropyrimidin-4-yl)-2-(oxan-4-yloxy)benzonitrile (930 mg, 3.0 mmol) in dioxane (25 mL) was added tert-butyl carbamate (450 mg, 3.8 mmol), Pd(OAc)2 (70 mg, 0.3 mmol), BINAP (590 mg, 0.9 mmol) and Cs2C03 (1550 mg, 4.8 mmol) at room temperature. The resulting mixture was stirred for 3 h at 120 C. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0 % to 66 % gradient) to yield tert-butyl N-[4- [3-cyano-4-(oxan-4-yloxy)phenyl]pyrimidin-2-yl]carbamate as an yellow solid (680 mg, 58 %). MS: m/z = 397.3 [M+H]+.
Computed Properties
Molecular Weight:124.14
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:124.063662883
Monoisotopic Mass:124.063662883
Topological Polar Surface Area:48.1
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Amino-6-methoxypyridine
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