2-NITRONICOTINIC ACID

Yellow solid

Compound 3 (16.8 g, 0.1 mol) was dissolved in acetonitrile (100 mL).Add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (24.9 g, 0.13 mol), Stir at room temperature for 2 hours.Compound 2 (17.18 g, 0.13 mol) was added, The temperature was raised to 90 ° C and kept for 6 hours.After completion of the reaction, the acetonitrile was evaporated to give an oily substance, and purified water (80 ml) was added thereto, and the mixture was stirred, and filtered, and rinsed with water.Compound 4 and dried to give 26.42g, 93.6percent yieldTo a solution of (R)-6-chloro-4-fluoroindan-1-ylamine hydrochloride (0.1 g) in methanol (3 mL) were added triethylamine (0.046 g) and benzaldehyde (0.048 g), and the mixture was stirred for 0.5 hours at 65° C. The reaction mixture was allowed to cool to room temperature, and to the mixture were added 2-Amino-N-[(R)-carbamoylphenylmethyl]-N-[(R)-6-chloro-4-fluoroindan-1-yl]nicotinamide To a solution of (R)-6-chloro-4-fluoroindan-1-ylamine hydrochloride (0.1 g) in methanol (3 mL) were added triethylamine (0.046 g) and benzaldehyde (0.048 g), and the mixture was stirred for 0.5 hours at 65° C. The reaction mixture was allowed to cool to room temperature, and to the mixture were added Triethylamine (0.046g) and benzaldehyde (0.048g) in addition to methanol (3mL) solution of (R) -6- chloro-4-fluoro-indan-1-ylamine hydrochloride(0.1g), at 65 It was stirred for 0.5 hours. The reaction mixture was allowed to cool to room temperature,

Molecular Weight:168.11
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:168.01710661
Monoisotopic Mass:168.01710661
Topological Polar Surface Area:96
Heavy Atom Count:12
Complexity:200
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes