Product
Supplier
Encyclopedia
Inquiry
Home > Encyclopedia > 6-Methyl-2-pyridinecarbonitrile

6-Methyl-2-pyridinecarbonitrile

6-Methyl-2-pyridinecarbonitrile structure

6-Methyl-2-pyridinecarbonitrile 

structure
  • CAS No:

    1620-75-3

  • Formula:

    C7H6N2

  • Chemical Name:

    6-Methyl-2-pyridinecarbonitrile

  • Synonyms:

    2-Pyridinecarbonitrile,6-methyl-;Picolinonitrile,6-methyl-;6-Methyl-2-pyridinecarbonitrile;2-Cyano-6-methylpyridine;6-Methyl-2-cyanopyridine;2-Methyl-6-cyanopyridine;6-Methylpicolinonitrile;6-Cyano-2-methylpyridine;NSC 26022

  • Categories:

    Pharmaceutical Intermediates  >  Heterocyclic Compound

Description

White Solid

6-Methyl-2-pyridinecarbonitrile Basic Attributes

118.14

118.14

216-588-9

26022

DTXSID60167284

29333990

Characteristics

36.7

0.8

Off-white Solid

1.08±0.1 g/cm3(Predicted)

72-74 °C

0°C

0°C

1.531

0.043mmHg at 25°C

Safety Information

III

6.1

UN 3439 6.1/PG III

3

36/37/38

26-36

Xi

P261-P305 + P351 + P338

H315-H319-H335

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

6-Methyl-2-pyridinecarbonitrile Use and Manufacturing

Methods of Manufacturing

General procedure: Benzonitrile 1a (1 mmol), Na2S*9H2O (1.2 mmol) and DMF (1 mL) were added into a 10 mL bottle. The reactor was placed in a heating magnetic stirrer at 130 C. After 2.5 h, by adding about 3 mL H2O after the reaction to disperse the solid product, the reaction mixture was extracted with EtOAc (3 x 3 mL), and the mixture was purified by column chromatography.

Uses

Intermediate in the preparation of selective cyclooxygenase-2 inhibitors and calcium antagonists

Computed Properties

Molecular Weight:118.14
XLogP3:0.8
Hydrogen Bond Acceptor Count:2
Exact Mass:118.053098200
Monoisotopic Mass:118.053098200
Topological Polar Surface Area:36.7
Heavy Atom Count:9
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 6-Methyl-2-pyridinecarbonitrile

Scan the QR Code to Share

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.