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GATIFLOXACIN MESYLATE

GATIFLOXACIN MESYLATE structure

CAS No:
316819-28-0
Formula:
C19H22FN3O4.CH4O3S
Chemical Name:
GATIFLOXACIN MESYLATE
Synonyms:
Gatifloxacin mesylate;Gatifloxacin (mesylate);Gatifloxacin mesilate;UNII-NZE1V6L7F9;Gatifloxacin mesylate [WHO-DD];NZE1V6L7F9;SCHEMBL18279977;DTXSID60581345;BCP28521;HY-10581B
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.Target: AntibacterialGatifloxacin (mesylate) is the mesylate salt of Gatifloxacin which is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Gatifloxacin had activity equal to that of tosufloxacin and activity more pote

GATIFLOXACIN MESYLATE Basic Attributes

Molecular Weight：

471.503

Exact Mass：

471.147552

Characteristics

PSA：

145

XLogP3：

2.95900

Drug Function and Efficacy

Gatifloxacin is a racemic compound of the 8-methoxyfluoroquinolone class. It has a broad spectrum of activity against Gram-negative and Gram-positive microorganisms in vitro. Its R- and S-enantiomers have the same antibacterial activity. The antibacterial effect of this product is through inhibiting bacterial DNA gyrase and topoisomerase IV, thereby inhibiting the replication, transcription and repair process of bacterial DNA. It has antibacterial activity against most strains of the following microorganisms: (1) Gram-positive bacteria: Staphylococcus aureus (limited to strains sensitive to methicillin), Streptococcus pneumoniae (strains sensitive to penicillin). (2) Gram-negative bacteria: Escherichia coli, Haemophilus influenzae and parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Neisseria gonorrhoeae, Proteus mirabilis. (3) Other microorganisms: Chlamydia pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Gatifloxacin Mesylate and Glucose Injection
Ingredients	The main ingredient of this product is gatifloxacin mesylate, its chemical name is: (±) 1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate, its structural formula is: Molecular formula: C19H22FN3O4·CH3SO3H Molecular weight: 471.51
Indication	1. This product can be used in combination with probenecid to slow down the elimination of gatifloxacin through the kidney. 2. When this product is used simultaneously with digoxin, no significant changes in the pharmacokinetics of gatifloxacin are observed, but the blood concentration of digoxin is found to be increased in some subjects. Therefore, the symptoms and signs of digoxin toxicity in patients taking digoxin should be monitored. For patients who show symptoms and signs of toxicity, the blood concentration of digoxin should be measured and the digoxin dose should be adjusted appropriately. However, it is not recommended to adjust the doses of the two drugs in advance.
Specifications	100ml: Gatifloxacin mesylate (calculated as gatifloxacin) 0.2g and glucose 5g
Manufacturer	Jiangsu Embrace Sicence & Technology Development Co., Ltd.

Gatifloxacin Mesylate Capsules
Ingredients	This product is gatifloxacin mesylate.
Indication	1. This product can be used in combination with probenecid to slow down the renal elimination of gatifloxacin. 2. When this product is used simultaneously with digoxin, no significant changes in the pharmacokinetics of gatifloxacin are observed, but increased digoxin blood concentrations are found in some subjects. Therefore, patients taking digoxin should be monitored for symptoms and signs of digoxin toxicity. For patients who show symptoms and signs of toxicity, the blood concentration of digoxin should be measured and the digoxin dose should be adjusted appropriately. However, it is not recommended to adjust the doses of the two drugs in advance. 3. The simultaneous use of gatifloxacin and drugs that affect glucose metabolism can increase the risk of abnormal blood glucose metabolism in patients (see Contraindications and Warnings: Abnormal Blood Glucose). Antidiabetic drugs: Pharmacodynamic changes that affect glucose metabolism have been observed after the combined use of glibenclamide and other hypoglycemic drugs. When glibenclamide is used in combination with gatifloxacin:
Specifications	0.2g (calculated as gatifloxacin)
Manufacturer	Henan Bainian Kangxin Pharmaceutical Co., Ltd.

Gatifloxacin Mesylate for Injection
Specifications	0.2g (based on gatifloxacin)
Manufacturer	Jiangsu Aosaikang Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shaoxing Jingxin Pharmaceutical Co., Ltd.

China
Active
Jiangsu Aosaikang Pharmaceutical Co., Ltd.

China
Active
Henan Kangtai Pharmaceutical Co., Ltd.

China
Active

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