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Rilmenidine

Rilmenidine structure

CAS No:
54187-04-1
Formula:
C10H16N2O
Chemical Name:
Rilmenidine
Synonyms:
2-Oxazolamine,N-(dicyclopropylmethyl)-4,5-dihydro-;N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine;S 3341;Rilmenidine;Oxaminozoline;Rilmenidene;NSC 664312
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

water soluble

Rilmenidine is an isourea.|Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.|Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION.

Rilmenidine Basic Attributes

Molecular Weight：

180.25

Exact Mass：

180.25

EC Number：

259-021-0

UNII：

P67IM25ID8

NSC Number：

664312

DSSTox ID：

DTXSID3045194

ATC Code：

C02AC06|C - Cardiovascular system

HScode：

2934999090

Characteristics

PSA：

33.6

XLogP3：

0.57

Appearance：

white solid

Density：

1.5±0.1 g/cm3

Melting Point：

106-107 °C

Boiling Point：

355.5±9.0 °C at 760 mmHg

Flash Point：

168.8±18.7 °C

Refractive Index：

1.711

Water Solubility：

H2O: 7.3 mg/mL

Storage Conditions：

Store at -20°C

Safety Information

wgk germany：

safety instructions：

22-24/25

RTECS Number：

RP7207400

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Drug Information

MeSH：

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

MeSH Entry Terms：

2-(N-(dicyclopropylmethyl)amino)oxazoline

Rilmenidine Use and Manufacturing

I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine

Computed Properties

Molecular Weight:180.25
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:180.126263138
Monoisotopic Mass:180.126263138
Topological Polar Surface Area:33.6
Heavy Atom Count:13
Complexity:219
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethanolamine

Thionyl chloride

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