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Betahistine mesylate

Betahistine mesylate structure

CAS No:
54856-23-4
Formula:
C8H12N2.2CH4O3S
Chemical Name:
Betahistine mesylate
Synonyms:
2-Pyridineethanamine,N-methyl-,methanesulfonate (1:2);2-Pyridineethanamine,N-methyl-,dimethanesulfonate;Betahistine mesylate;Merislon
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

White or almost white, crystalline powder, very hygroscopic.

Betahistine mesilate is an aralkylamine.|A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

Betahistine mesylate Basic Attributes

Molecular Weight：

328.41

Exact Mass：

328.076263

EC Number：

259-377-7

UNII：

X1L0E3R43Y

DSSTox ID：

DTXSID1045588

HScode：

2933399090

Characteristics

PSA：

150.42000

XLogP3：

2.40400

Melting Point：

112°C

Boiling Point：

210.9ºC at 760 mmHg

Flash Point：

96.7ºC

Water Solubility：

almost transparency

Toxicity：

Oral-rat LD50: 3030 mg/kg; Oral-Mouse LD50: 500 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Safety Information

RTECS Number：

UT2970200

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Aequamen

Betahistine mesylate Use and Manufacturing

Vasodilatator;H1 agonist

Computed Properties

Molecular Weight:328.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:328.07627871
Monoisotopic Mass:328.07627871
Topological Polar Surface Area:150
Heavy Atom Count:20
Complexity:176
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

1. Improvement of inner ear circulation disorders: In the marmot model, blood flow increased to 148% 30 minutes after intraperitoneal administration. 2. Increased cochlear blood flow in marmots with endolymphatic edema: Cochlear blood flow increased from 5.5ml/(100g·min) to 8.1ml/(100g·min), due to the relaxation of the smooth muscle of the radial arteries of the cochlea. 3. Improvement of brain blood flow: In the rhesus monkey experiment, after intravenous injection, the blood flow of the cerebral and cerebellar tissues increased from 70.4ml/(100g·min) to 81.1ml/(100g·min) and from 73.2ml/(100g·min) to 84.0ml/(100g·min), respectively.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Betahistine Mesylate Tablets
Ingredients	Betahistine mesylate
Indication	This trial has not been conducted and there are no reliable references.
Specifications	6mg
Manufacturer	Guangdong Shixin Pharmaceutical Co., Ltd.

Betahistine mesylate
Manufacturer	Guangdong Shixin Pharmaceutical Co., Ltd.

Betahistine Mesylate Tablets
Ingredients	Betahistine mesylate
Indication	This trial has not been conducted and there are no reliable references.
Specifications	6mg
Manufacturer	Guangdong Shixin Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

China CHINO PHARMA Ltd

China
Active
Xiamen Encheng Tragacanth Limited Company

China
Active
Lanxiha Sanlian Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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CAS No.: 54856-23-4

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Betahistine Mesilate54856-23-4

CAS No.: 54856-23-4

Grade: Pharmaceutical Grade

Content: 99%

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