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Lorcainide

Lorcainide structure

CAS No:
59729-31-6
Formula:
C22H27ClN2O
Chemical Name:
Lorcainide
Synonyms:
Benzeneacetamide,N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]-;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide;Lorcainide;Lorcamide;1224882-67-0
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Solid

Lorcainide is a member of acetamides.

Lorcainide Basic Attributes

Molecular Weight：

370.921

Exact Mass：

370.92

UNII：

KGJ2T0N7IQ

DSSTox ID：

DTXSID2023226

ATC Code：

C - Cardiovascular system

Characteristics

PSA：

23.6

XLogP3：

4.85

Appearance：

Solid

Density：

1.161g/cm3

Melting Point：

263 °C

Boiling Point：

503ºC at 760 mmHg

Flash Point：

258ºC

Refractive Index：

1.594

Toxicity：

LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom)

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

4'-chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide

Lorcainide Use and Manufacturing

Anti-arrhythmic drugs, both local anesthesia. Used for ventricular arrhythmias, premature ventricular contractions, recurrent ventricular tachycardia, but also for atrial premature beats, supraventricular tachycardia, intractable arrhythmias.

Computed Properties

Molecular Weight:370.9
XLogP3:4.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:370.1811912
Monoisotopic Mass:370.1811912
Topological Polar Surface Area:23.6
Heavy Atom Count:26
Complexity:433
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

4-Chloroaniline

Methyl acrylate