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Indobufen

Indobufen structure

CAS No:
63610-08-2
Formula:
C18H17NO3
Chemical Name:
Indobufen
Synonyms:
Benzeneacetic acid,4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-;Benzeneacetic acid,4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-,(±)-;4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-ethylbenzeneacetic acid;Indobufen;Ibustrin;1-Oxo-2-[p-[(α-ethyl)carboxymethyl]phenyl]isoindoline;K 3920;K 2930;2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric acid;2-(4-(1-Oxoisoindolin-2-yl)phenyl)butanoic acid;36690-96-7
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

Description

Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1].

Indobufen is a member of isoindoles.|Indobufen has been used in trials studying the supportive care and prevention of Atrial Fibrillation.

Indobufen Basic Attributes

Molecular Weight：

295.33

Exact Mass：

295.33

EC Number：

264-364-4

DSSTox ID：

DTXSID7057789

ATC Code：

B - Blood and blood forming organs

HScode：

2918300090

Characteristics

PSA：

57.6

XLogP3：

3.1

Density：

1.3±0.1 g/cm3

Melting Point：

183 °C

Boiling Point：

103-105°C at 2 mmHg

Flash Point：

267.1±30.1 °C

Refractive Index：

1.630

Safety Information

wgk germany：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 31 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

MeSH Entry Terms：

2-(4-(1-oxo-2-isoindolinyl)phenyl)butyric acid

Indobufen Use and Manufacturing

Indobufen is a platelet aggregation inhibitor. Indobufen is the anticoagulant drug and platelet aggregation inhibitor, which has anti-inflammatory analgesic effect. Indobufen is used as an antithrombotic.

Computed Properties

Molecular Weight:295.3
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:295.12084340
Monoisotopic Mass:295.12084340
Topological Polar Surface Area:57.6
Heavy Atom Count:22
Complexity:428
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Potassium carbonate

Phthalic anhydride

Drug Function and Efficacy

It can inhibit the release of some platelet activating factors (such as ADP, 5-HT, platelet factor 4, β-platelet protein, etc.) and affect arachidonic acid metabolism to resist platelet aggregation, but it does not affect the blood concentration of PGI2. It has no effect on various parameters of blood coagulation, but can moderately prolong bleeding time, which can be restored after stopping the drug.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Indobufen Tablets
Ingredients	The main ingredient of this product is indobufen.
Indication	Avoid taking it simultaneously with other anticoagulants or aspirin.
Specifications	0.2g

Indobufen
Manufacturer	Huadong Medicine (Xi'an) Bodyguard Pharmaceutical Co., Ltd.

Indobufen Tablets
Specifications	0.2g*7s
Manufacturer	Hangzhou Zhongmeihuadong Pharmaceutical Jiangdong Co., Ltd.

Registered Holders

Xuancheng Menovo Pharmaceutical Co., Ltd.

China
Active
Sichuan Yinodabo Pharmaceutical Technology Co., Ltd.

China
Active
Inner Mongolia JingDong Pharmaceutical Co., Ltd.

China
Active

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