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Cloricromen

Cloricromen structure

CAS No:
68206-94-0
Formula:
C20H26ClNO5
Chemical Name:
Cloricromen
Synonyms:
Acetic acid,2-[[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]-,ethyl ester;Acetic acid,[[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]-,ethyl ester;AD 6;AD 6 (pharmaceutical);8-Chlorocarbochromen;Cloricromene;Cloricromen;(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide);74273-42-0
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

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Description

Cloricromen is a member of coumarins.

Cloricromen Basic Attributes

Molecular Weight：

395.88

Exact Mass：

395.88

UNII：

B9454PE93C

DSSTox ID：

DTXSID2048373

ATC Code：

B - Blood and blood forming organs

Characteristics

PSA：

65.1

XLogP3：

3.58100

Appearance：

white solid

Density：

1.189g/cm3

Melting Point：

147-148 °C

Boiling Point：

514.1ºC at 760mmHg

Flash Point：

264.7ºC

Refractive Index：

1.532

Water Solubility：

DMSO: 17 mg/mL

Storage Conditions：

2-8°C

Safety Information

wgk germany：

hazard class code：

RTECS Number：

AF8970000

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

MeSH Entry Terms：

8-chloro-3-beta-diethylaminoethyl-4-methyl-7-ethyoxycarbonymethoxycoumarin

Cloricromen Use and Manufacturing

Coronary dilatation and antithrombotic drugs. It can enhance the production of prostacyclin in the vascular endothelium and enhance the inhibition of polymorphonuclear leukocytes in inhibiting platelet aggregation. Can significantly improve exercise tolerance and reduce the use of nitrate in patients with angina. Used for anticoagulation.

Computed Properties

Molecular Weight:395.9
XLogP3:3.8
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:395.1499506
Monoisotopic Mass:395.1499506
Topological Polar Surface Area:65.1
Heavy Atom Count:27
Complexity:561
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes