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Enprostil

Enprostil structure

CAS No:
73121-56-9
Formula:
C23H28O6
Chemical Name:
Enprostil
Synonyms:
4,5-Heptadienoic acid,7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]-5-oxocyclopentyl]-,methyl ester,rel-;4,5-Heptadienoic acid,7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-butenyl]-5-oxocyclopentyl]-,methyl ester,rel-;Enprostil;Gardrin;RS 84135-004;RS 84-135;Gardrine;Camleed;RS 84135;Fundyl;Syngard;103617-06-7;82444-04-0;84872-70-8
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.

Enprostil Basic Attributes

Molecular Weight：

400.46

Exact Mass：

400.46

ATC Code：

A - Alimentary tract and metabolism

Characteristics

PSA：

93.06000

XLogP3：

1.45

Density：

1.2±0.1 g/cm3

Melting Point：

<46 °C

Boiling Point：

552.9±50.0 °C at 760 mmHg

Flash Point：

185.7±23.6 °C

Refractive Index：

1.586

Drug Information

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

MeSH Entry Terms：

Enprostil

Enprostil Use and Manufacturing

It is a synthetic dehydrogenated PGE2, which can inhibit the basic gastric acid of animals and humans and the secretion of gastric acid caused by histamine, pentagastrin and food. Used for gastritis, gastric ulcer and duodenal ulcer.

Computed Properties

Molecular Weight:400.5
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:400.18858861
Monoisotopic Mass:400.18858861
Topological Polar Surface Area:93.1
Heavy Atom Count:29
Complexity:613
Undefined Atom Stereocenter Count:4
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:No