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Enalapril

Enalapril structure

CAS No:
75847-73-3
Formula:
C20H28N2O5
Chemical Name:
Enalapril
Synonyms:
L-Proline,N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-;L-Proline,1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-,(S)-;N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline;Enalapril;Enarenal;77549-58-7;172964-46-4
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Enalapril is an angiotensin converting enzyme (ACE) inhibitorTarget: ACEEnalapril belongs to a class of medications called angiotensin converting enzyme inhibitors. Normally angiotensin I is converted to angiotensin II by angiotensin converting enzyme (ACE). Angiotensin II constricts blood vessels, increasing blood pressure. By inhibiting ACE, Enalapril decreases levels of angiotensin II leading to less vasoconstriction and decreased blood pressure.

Enalapril Basic Attributes

Molecular Weight：

376.45

Exact Mass：

376.45

EC Number：

616-271-9

Characteristics

PSA：

95.9

XLogP3：

2.1

Density：

1.2±0.1 g/cm3

Melting Point：

143-144 °C

Boiling Point：

582.3±50.0 °C at 760 mmHg

Flash Point：

306.0±30.1 °C

Refractive Index：

1.550

Water Solubility：

soluble in water at 25mg/ml

Storage Conditions：

Store below 40 deg C (104 deg F), preferably between 15 and 30 deg C (59 and 86 deg F), unless otherwise specified by manufacturer. /Enalaprilat injection/

Vapor Pressure：

1.06X10-12 mm Hg at 25 °C (est)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

TW3665500

Stability/Shelf Life：

The manufacturer recommends that enalapril maleate tablets be stored in tight containers at a temperature <30 deg C and that transient exposure to temperatures warmer than 50 deg C be avoided. The tablets should be protected from moisture. The tablets have an expiration date of 30 mos following the date of manufacture when stored at <30 deg C. The manufacturer states that extemporaneous preparation of oral solutions of enalapril maleate should be avoided since the drug is not sufficiently

Precautionary statement(s)：

P280

Hazard Statements：

H317-H361

Enalapril Use and Manufacturing

angiotensin converting enzyme inhibitor

Material

Maleic anhydride

2-Methoxyethanol

Propylene

Ethyl acetate

Acetic acid

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