 Home > Encyclopedia > Perindoprilat

Perindoprilat

Perindoprilat structure

CAS No:
95153-31-4
Formula:
C17H28N2O5
Chemical Name:
Perindoprilat
Synonyms:
1H-Indole-2-carboxylic acid,1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,7aS)-;1H-Indole-2-carboxylic acid,1-[2-[(1-carboxybutyl)amino]-1-oxopropyl]octahydro-,[2S-[1[R*(R*)],2α,3aβ,7aβ]]-;(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid;S 9780;Perindoprilat
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

White to Off-White Solid

Perindoprilat is a dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a drug metabolite. It is an organic heterobicyclic compound, a dipeptide, a dicarboxylic acid and a L-alanine derivative.|The active metabolite of the prodrug [Perindopril].|Perindoprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of perindoprilat is as an Angiotensin-converting Enzyme Inhibitor.|Perindoprilat is a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Perindoprilat inhibits ACE and, thus, the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.

Perindoprilat Basic Attributes

Molecular Weight：

340.41

Exact Mass：

340.41

UNII：

2UV6ZNQ92K

NCI Thesaurus Code：

C66357

HScode：

2933999552

Characteristics

PSA：

107

XLogP3：

2.37

Density：

1.2±0.1 g/cm3

Melting Point：

153-155°C

Boiling Point：

568.1±45.0 °C at 760 mmHg

Flash Point：

297.4±28.7 °C

Refractive Index：

1.535

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

Drug Information

MeSH：

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

perindoprilat

Perindoprilat Use and Manufacturing

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical]

Computed Properties

Molecular Weight:340.4
XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:340.19982200
Monoisotopic Mass:340.19982200
Topological Polar Surface Area:107
Heavy Atom Count:24
Complexity:495
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Perindoprilat

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Perindoprilat

CAS No.: 95153-31-4

Content: 99.00%

Inquiry